基于肝功能、IgA、IgM、IgG水平分析双环醇联合更昔洛韦治疗对EB病毒相关IM患儿的应用效果  

Analysis of the Application Effect of Bicyclol Combined with Ganciclovir in the Treatment of EB Virus-Related Infectious Mononucleosis in Children Based on Liver Function,IgA,IgM,and IgG Levels

作　　者：章秀珍 胡灿艳 蔡磊 ZHANG Xiuzhen;HU Canyan;CAI Lei(Department of Pediatrics,Susong County People’s Hospital,Anqing Anhui 246500,China)

机构地区：[1]宿松县人民医院儿科,安徽安庆246500

出　　处：《昆明医科大学学报》2025年第3期97-102,共6页Journal of Kunming Medical University

基　　金：安徽省卫生厅科研计划项目(外128)。

摘　　要：目的 探究基于肝功能、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)水平分析双环醇联合更昔洛韦治疗对EB病毒相关传染性单核细胞增多症(IM)患儿的应用效果。方法 选取2019年1月至2024年1月宿松县人民医院收治的150例EB病毒感染IM患儿作为研究对象,并采用数字表达法对其行随机分组,分为对照组和观察组(均n=75)。患儿入院后均接受常规对症治疗,对照组患儿采用更昔洛韦治疗,观察组患儿在对照组基础上联合双环醇治疗;两组均接受7 d的治疗。对比两组的治疗效果;对比两组治疗前后肝功能指标、免疫球蛋白指标、生活质量;对比两组不良反应率。结果 观察组治疗总有效率为93.33%(70/75),高于对照组的61.33%(46/75),P <0.05;治疗后两组肝功能指标均有显著降低,且观察组更低(均P <0.05);治疗后两组免疫球蛋白指标均有显著升高,且观察组更高(均P <0.05);治疗后两组生活质量各项评分均有显著升高,且观察组更高(均P <0.05);观察组总不良反应率为6.67%(5/75)高于对照组的5.33%(4/75),但二者对比差异无统计学意义(P> 0.05)。结论 对EB病毒相关IM应用双环醇联合更昔洛韦治疗,可显著提升患儿治疗效果,改善患儿的肝功能和免疫球蛋白指标,提高患儿生活质量,且不良反应相对较低,临床疗效和安全性均较高。Objective To explore the application effect of bicyclol combined with ganciclovir in the treatment of children with Epstein-barr virus related infectious mononucleosis(IM)based on liver function,immunoglobulin A(IgA),immunoglobulin M(IgM)and immunoglobulin G(IgG)levels.Methods A total of 150 children with EB virus infected and IM admitted to the People's Hospital of Susong County from January 2019 to January 2024 were selected as the study subjects.Random grouping was performed using a digital expression method,dividing them into a control group and an observation group(n=75).All children received routine symptomatic treatment upon admission.The control group were treated with ganciclovir,while the observation group were treated with bicyclol in addition to ganciclovir.Both groups underwent treatment for 7 days.The therapeutic effects,liver function indexes,immunoglobulin indexes,quality of life,and adverse reaction rates were compared between the two groups.The therapeutic effects,liver function indicators,immunoglobulin indicators,quality of life,and adverse reaction rates were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.33%(70/75),which was significantly higher than that of control group(61.33%(46/75)(P<0.05)).After treatment,the liver function indexes of both groups were significantly decreased,and the observation group showing lower levels(all P<0.05).After treatment,immunoglobulin indexes were significantly increased in both groups,with the observation group having higher levels(P<0.05).After treatment,the scores of life quality in both groups significantly increased,and those in observation group were higher(all P<0.05).Quality of life scores significantly improved in both groups,with the observation group achieving higher scores(P<0.05).The total adverse reaction rate in the observation group was 6.67%(5/75),compared to 5.33%(4/75)in the control group,but there was no significant difference between the two groups(P>0.05).Conclusion The appl

关 键 词：EB病毒 传染性单核细胞增多症 肝功能 免疫功能 疗效 

分 类 号：R320.2430[医药卫生—人体解剖和组织胚胎学]