基于“瘀毒”理论探讨中性粒细胞胞外诱捕网对肺纤维化的影响  

Exploration on Effect of Neutrophil Extracellular Traps on Pulmonary Fibrosis Based on the Theory of“Stasis and Toxicity”

作　　者：闫国涛 徐飞 刘骅漫 张伟[2] 贾新华[2] YAN Guotao;XU Fei;LIU Huaman;ZHANG Wei;JIA Xinhua(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学,山东济南250355 [2]山东中医药大学附属医院,山东济南250014

出　　处：《山东中医杂志》2025年第4期378-384,共7页Shandong Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(编号:81804034);山东省自然科学基金项目(编号:ZR2020MH353);青年岐黄学者培养工程(批文号:国中医药人教函〔2022〕256号);泰山学者工程专项经费资助项目(批文号:tsqn202306393);山东省中医药高层次人才培育项目(批文号:鲁卫函〔2023〕143号);齐鲁卫生与健康领军人才培育工程项目(批文号:鲁卫人才字〔2020〕3号)。

摘　　要：肺纤维化(PF)是一种慢性、进展性且不可逆的疾病,本文基于“瘀毒”理论,以中性粒细胞胞外诱捕网(NETs)为切入点,从NETs可促进血管生成、增强凝血、促使血栓形成,以及驱动上皮损伤、促进成纤维细胞活化、激活炎症反应等方面,讨论NETs在PF发生发展中的作用,总结NETs在PF“瘀毒”理论中的关键病机,探讨“瘀毒”对PF的影响,为中西医结合预防和治疗PF提供新思路。Pulmonary fibrosis(PF)is a chronic,progressive,and irreversible lung disease.Based on the theory of“stasis and toxicity”,this paper takes neutrophil extracellular traps(NETs)as the breakthrough point,discusses the role of NETs in the occurrence and development of PF from the aspects that NETs can contribute to angiogenesis,enhance coagulation,promote thrombosis,drive epithelial injury,stimulate fibroblast activation,and activate inflammatory responses,and summarizes the key pathogenesis of NETs in the theory of“stasis and toxicity”and explore the role of NETs in the pathogenesis of PF,with a prospect of providing novel insights for the prevention and treatment of PF.

关 键 词：中性粒细胞胞外诱捕网 肺纤维化 瘀毒 血管新生 纤溶失衡 炎症免疫 

分 类 号：R259.63[医药卫生—中西医结合]