八珍汤联合HAART治疗HIV/AIDS气血两虚证患者临床研究  

Clinical Study on Bazhen Decoction(八珍汤)Combined with HAART in the Treatment of HIV/AIDS Patients with Deficiency of Qi and Blood Syndrome

作　　者：周施施 高海英[2] 刘雯静 王永勤[2] 尹志红[2] 冯静[2] ZHOU Shishi;GAO Haiying;LIU Wenjing;WANG Yongqin;YIN Zhihong;FENG Jing(School of Clinical Medicine,Shandong Second Medical University,Weifang 261053,China;Department of Infectious Diseases,Weifang People’s Hospital,Weifang 261044,China)

机构地区：[1]山东第二医科大学临床医学院,山东潍坊261053 [2]潍坊市人民医院感染性疾病科,山东潍坊261044

出　　处：《山东中医杂志》2025年第4期416-421,436,共7页Shandong Journal of Traditional Chinese Medicine

基　　金：山东省医药卫生科技发展计划项目(编号:2017WS778);潍坊市卫生计生委科研项目(编号:wfws js_2018_001)。

摘　　要：目的:探讨八珍汤联合高效抗反转录病毒疗法(HAART)治疗对气血两虚证人类免疫缺陷病毒感染/获得性免疫缺陷综合征(HIV/AIDS)患者症状及生存质量的影响。方法:按随机数字表法将80例HIV/AIDS气血两虚证患者分为对照组和观察组各40例,观察组采用八珍汤联合HAART进行治疗,对照组采用HAART方案治疗。比较两组治疗前后症状体征积分、生存质量系列得分、体质量指数(BMI)及CD4+T淋巴细胞计数,评估治疗方案的安全性。结果:治疗后,两组患者症状体征积分较治疗前均降低(P<0.05),且观察组低于对照组(P<0.05);治疗后,观察组在总的健康感知程度、心理领域、社会关系领域及生存质量总分四个方面得分均较治疗前上升(P<0.05),对照组社会关系领域及生存质量总分均较治疗前上升(P<0.05),观察组生存质量总分及总的生活质量、生理、心理、环境得分高于对照组,差异有统计学意义(P<0.05);治疗后,观察组BMI低于对照组(P<0.05);治疗后,两组CD4+T淋巴细胞计数均上升(P<0.05),且观察组高于对照组(P<0.05)。结论:八珍汤联合HAART治疗方案可以有效改善气血两虚证HIV/AIDS患者症状体征,提高生存质量,安全性好。Objective:To investigate the effect of Bazhen Decoction(八珍汤)combined with highly active antiretroviral therapy(HAART)on the symptoms and quality of life of patients with human immunodeficiency virus infection/acquired immunodeficiency syndrome(HIV/AIDS)with deficiency of qi and blood.Methods:80 HIV/AIDS patients with deficiency of qi and blood syndrome were divided into the control group and the observation group by using random number table method,with 40 cases in each group,the observation group was treated with Bazhen Decoction combined with HAART,and the control group was treated with HAART.Symptom and sign scores,quality of life series scores,body mass index(BMI)and CD4+T lymphocyte count were compared between the two groups before and after treatment,and the safety of the treatment regimen was evaluated.Results:After treatment,the scores of symptoms and signs in both groups were lower than those before treatment(P<0.05),and the observation group was lower than the control group(P<0.05).After treatment,the total health perception degree,psychological field,social relation field and total score of quality of life in the observation group were increased compared with those before treatment(P<0.05),and the social relation field and total score of quality of life in the control group were increased compared with those before treatment(P<0.05).The total score of quality of life and the scores of overall quality of life,physiology,psychology and environment in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,BMI of the observation group was lower than that of the control group(P<0.05).After treatment,CD4+T lymphocyte count increased in both groups(P<0.05),and the observation group was higher than the control group(P<0.05).Conclusion:Bazhen Decoction combined with HAART can effectively relieve the symptoms and signs of HIV/AIDS patients with qi and blood deficiency syndrome,improve the quality of life and it is of good

关 键 词：八珍汤 获得性免疫缺陷综合征 人类免疫缺陷病毒 气血两虚证 高效抗反转录病毒疗法 

分 类 号：R259.129.1[医药卫生—中西医结合]