活血祛斑丸治疗颈动脉粥样硬化斑块疗效报道  

Report on Therapeutic Effect of Huoxue Quban Pill(活血祛斑丸)on Carotid Atherosclerotic Plaque

作　　者：殷镜海[1] 殷颖[1] YIN Jinghai;YIN Ying(Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学附属医院,山东济南250014

出　　处：《山东中医杂志》2025年第4期470-473,480,共5页Shandong Journal of Traditional Chinese Medicine

摘　　要：目的:探讨活血祛斑丸对颈动脉粥样硬化斑块和颈部动脉血流量的影响。方法:回顾158例颈动脉粥样硬化斑块患者颈动脉超声检查结果,根据疗程内服药情况分为对照组、西药组和中药组,对照组不服用药物,或每年间断服用中西医降脂控制斑块药物≤3个月,西药组每年规律服用降脂控制斑块西药≥9个月,中药组在西药组基础上加用活血祛斑丸。以1年为1个疗程,记为1例次,单侧斑块1个疗程内的变化记1频次,以频次作为统计样本。观察三组疗程前后颈动脉粥样硬化斑块变化情况及颈动脉、椎动脉血流量。结果:中药组的双侧颈动脉粥样硬化斑块长度和厚度均减少(P<0.05),西药组左侧颈动脉粥样硬化斑块厚度略有增加(P<0.05),对照组双侧颈动脉粥样硬化斑块长度和厚度均有所增加(P<0.05)。组间比较,治疗后西药组右侧动脉粥样硬化斑块厚度小于对照组(P<0.05),中药组斑块长度、厚度改变有效者最多,其次为西药组,差异有统计学意义(P<0.05)。三组颈动脉和椎动脉血流量改变效果比较,差异具有统计学意义(P<0.05)。结论:活血祛斑丸可有效减小颈动脉粥样硬化斑块,增加脑部供血。Objective:To investigate the effect of Huoxue Quban Pill(活血祛斑丸)on carotid atherosclerotic plaque and the neck blood flow.Methods:A retrospective analysis was conducted on carotid artery ultrasound of 158 patients with cervical vascular plaques.According to the medication situation during the treatment course,they were divided into the control group,the western medicine group and the traditional Chinese medicine group.The control group did not take any medication or took lipid-lowering and plaque-controlling drugs of both western and traditional Chinese medicine for no more than 3 months each year.The western medicine group took lipid-lowering and plaque-controlling western medicine regularly for no less than 9 months each year.The traditional Chinese medicine group took Huoxue Quban Pills on the basis of the treatment of the western medicine group.One year was defined as one treatment course and was recorded as one case.The changes of unilateral plaque within one course of treatment were recorded as one frequency,and the frequency was used as the statistical sample.The changes of carotid atherosclerotic plaques and the blood flow of carotid and vertebral arteries before and after the treatment course in the three groups were observed.Results:The length and thickness of bilateral carotid atherosclerotic plaques decreased in the traditional Chinese medicine group(P<0.05).The thickness of left carotid atherosclerotic plaques increased slightly in the western medicine group(P<0.05),and the length and thickness of bilateral carotid atherosclerotic plaques increased in the control group(P<0.05).The thickness of the right atherosclerotic plaque in the western medicine group was lower than that in the control group after treatment(P<0.05).The number of effective cases of plaque length and thickness change in the traditional Chinese medicine group was the greatest,followed by the western medicine group,and the difference was statistically significant(P<0.05).The difference of blood flow of carotid artery and ver

关 键 词：颈动脉 动脉粥样硬化斑块 活血祛斑丸 血流量 

分 类 号：R259.431.2[医药卫生—中西医结合]