中医药靶向调控PI3K/Akt信号通路治疗非酒精性脂肪性肝病研究进展  

Research Progress of Traditional Chinese Medicine Targeted Regulation of PI3K/Akt Signaling Pathway in Treatment of Non-Alcoholic Fatty Liver Disease

作　　者：马紫慧 张思宁 张晓蕾 马国海 商洪涛[1] MA Zihui;ZHANG Sining;ZHANG Xiaolei;MA Guohai;SHANG Hongtao(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China)

机构地区：[1]南京中医药大学附属医院,江苏南京210029

出　　处：《山东中医杂志》2025年第4期481-488,共8页Shandong Journal of Traditional Chinese Medicine

基　　金：江苏省中医院科技创新项目(编号:Y22067)。

摘　　要：非酒精性脂肪性肝病(NAFLD)是一种常见的代谢紊乱性肝病,其发病机制涉及肝脏胰岛素抵抗、炎症反应、氧化应激、细胞自噬异常等多方面。磷脂酰肌醇3激酶(PI3K)/Akt信号通路是细胞内重要的信号传导通路,参与多种生物学过程。现有研究表明,PI3K/Akt信号通路能够多层次、多途径、多靶点影响NAFLD病情进展。中医药通过靶向调控PI3K/Akt信号通路,可以改善NAFLD胰岛素抵抗及糖脂代谢、缓解炎症、减轻氧化应激、调控自噬,从而有效改善肝脏脂质沉积等病理变化,防治NAFLD。参考文献61篇。Non-alcoholic fatty liver disease(NAFLD)is a prevalent metabolic disorder.Its pathogenesis involves liver insulin resistance,inflammatory responses,oxidative stress,and dysregulated autophagy,etc.The phosphatidyl inositol 3-kinase(PI3K)/Akt signaling pathway serves as a critical intracellular signaling pathway involved in a variety of biological processes.Current researches have indicated that the PI3K/Akt signaling pathway can affect the progression of NAFLD at multiple levels,through multiple pathways and multiple targets.Through targeted regulation of PI3K/Akt signaling pathway,traditional Chinese medicine can improve insulin resistance,improve glucose and lipid metabolism,relieve inflammation,alleviate oxidative stress,and regulate autophagy.Consequently,it effectively reduces liver lipid accumulation and other pathological changes,offering prevention and treatment of NAFLD.There are 61 references.

关 键 词：中医药 磷脂酰肌醇3激酶 PI3K/AKT信号通路 非酒精性脂肪性肝病 胰岛素抵抗 炎症反应 氧化应激 细胞自噬 

分 类 号：R259.755[医药卫生—中西医结合]