Copper-Bearing Metal-Organic Framework with Mucus-Penetrating Function for the Multi-Effective Clearance of Mucosal Colonized Helicobacter pylori  

作　　者：Chunxi Shu Wei Zhang Yiwei Zhang Yu Li Xinbo Xu Yanan Zhou Yue Zhang Qin Zhong Cong He Yin Zhu Xiaolei Wang 

机构地区：[1]Department of Gastroenterology,The First Affiliated Hospital,Jiangxi Medical College Nanchang University,Nanchang 330006,China [2]Postdoctoral Innovation Practice Base,The First Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang 330006,China [3]The National Engineering Research Center for Bioengineering Drugs and the Technologies,Institute of Translational Medicine,Nanchang University,Nanchang 330088,China

出　　处：《Research》2025年第1期164-180,共17页研究(英文)

基　　金：funded by the National Natural Science Foundation of China(grant no.82170580 to Y.Z.);the Key Research and Development Program of Jiangxi Province(20212BBG73004 to X.W.);the Postdoctoral Fellowship Program of CPSF(GZB20230283 to W.Z.).

摘　　要：Helicobacter pylori colonizes over 50%of people worldwide.Biofilm formation through penetrating gastric mucus and resistance acquired by H.pylori markedly reduces the efficacy of traditional antibiotics.The present triple therapy and bismuth-based quadruple therapy inevitably causes intestinal flora disturbance and fails to address the excessive H.pylori-triggered inflammatory response.Herein,a mucus-permeable therapeutic platform(Cu-MOF@NF)that consists of copper-bearing metal-organic framework(Cu-MOF)loaded with nitrogen-doped carbon dots and naturally active polysaccharide fucoidan is developed.The experimental results demonstrate that Cu-MOF@NF can penetrate the mucus layer and hinder H.pylori from adhering on gastric epithelial cells of the stomach.Notably,released Cu2+can degrade the polysaccharides in the biofilm and interfere with the cyclic growing mode of"bacterioplankton↔biofilm",thereby preventing recurrent and persistent infection.Compared with traditional triple therapy,the Cu-MOF@NF not only possesses impressive antibacterial effect(even include multidrug-resistant strains),but also improves the inflammatory microenvironment without disrupting the balance of intestinal flora,providing a more efficient,safe,and antibiotic-free new approach to eradicating H.pylori.

关 键 词：triple therapy mucus penetrating function penetrating gastric mucus mucosal colonized Helicobacter pylori copper bearing metal organic framework helicobacter pylori multi effective clearance traditional antibioticsthe 

分 类 号：O641[理学—物理化学] R318[理学—化学]