Gut Microbiota Improves Prognostic Prediction in Critically Ⅲ COVID-19 Patients Alongside Immunological and Hematological Indicators  

作　　者：Jiaxin Zhong Li Guo Yeming Wang Xuan Jiang Chun Wang Yan Xiao Ying Wang Fei Zhou Chao Wu Lan Chen Xinming Wang Jianwei Wang Bin Cao Mingkun Li LiLi Ren 

机构地区：[1]Beijing Institute of Genomics,Chinese Academy of Sciences,and China National Center for Bioinformation,Beijing,China [2]University of Chinese Academy of Sciences,Beijing,China [3]National Health Commission Key Laboratory of Systems Biology of Pathogens,State Key Laboratory of Respiratory Health and Multimorbidity and Christophe Mérieux Laboratory,National Institute of Pathogen Biology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China [4]Key Laboratory of Respiratory Disease Pathogenomics,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China [5]Department of Pulmonary and Critical Care Medicine,Center of Respiratory Medicine,China-Japan Friendship Hospital,Capital Medical University,Beijing,China [6]National Center for Respiratory Medicine,State Key Laboratory of Respiratory Health and Multimorbidity,National Clinical Research Center for Respiratory Diseases,Institute of Respiratory Medicine,Chinese Academy of Medical Sciences,Department of Pulmonary and Critical Care Medicine,Center of Respiratory Medicine,China-Japan Friendship Hospital,Beijing,China

出　　处：《Research》2025年第1期193-204,共12页研究(英文)

基　　金：supported by the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2019PT310029);Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2023-I2M-2-001);the National Natural Science Foundation of China(82161148009);the Fundamental Research Funds for the Central Universities(3332021092);the Strategic Priority Research Program of Chinese Academy of Sciences(grant no.XDB38030400);the Key Collaborative Research Program of the Alliance of International Science Organizations(ANSO-CR-KP-2022-09).

摘　　要：The gut microbiota undergoes substantial changes in COVID-19 patients;yet,the utility of these alterations as prognostic biomarkers at the time of hospital admission,and its correlation with immunological and hematological parameters,remains unclear.The objective of this study is to investigate the gut microbiota's dynamic change in critically ill patients with COVID-19 and evaluate its predictive capability for clinical outcomes alongside immunological and hematological parameters.In this study,anal swabs were consecutively collected from 192 COVID-19 patients(583 samples)upon hospital admission for metagenome sequencing.Simultaneously,blood samples were obtained to measure the concentrations of 27 cytokines and chemokines,along with hematological and biochemical indicators.Our findings indicate a significant correlation between the composition and dynamics of gut microbiota with disease severity and mortality in COVID-19 patients.Recovered patients exhibited a higher abundance of Veillonella and denser interactions among gut commensal bacteria compared to deceased patients.Furthermore,the abundance of gut commensal bacteria exhibited a negative correlation with the concentration of proinflammatory cytokines and organ damage markers.The gut microbiota upon admission showed moderate prognostic prediction ability with an AUC of 0.78,which was less effective compared to predictions based on immunological and hematological parameters(AUC 0.80 and 0.88,respectively).Noteworthy,the integration of these three datasets yielded a higher predictive accuracy(AUC 0.93).Our findings suggest the gut microbiota as an informative biomarker for COVID-19 prognosis,augmenting existing immune and hematological indicators.

关 键 词：prognostic biomarkers critically ill patients hematological parameters COVID gut microbiota immunological parameters gut microbiotas dynamic change 

分 类 号：R563.1[医药卫生—呼吸系统]