Hydrogel-Encapsulated Pancreatic Islet Cells as a Promising Strategy for Diabetic Cell Therapy  

作　　者：Zhikun Huan Jingbo Li Zhiqiang Luo Yunru Yu Ling Li 

机构地区：[1]Department of Endocrinology,Zhongda Hospital,School of Medicine,Southeast University,Nanjing 210009,China [2]State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China [3]Pharmaceutical Sciences Laboratory,Åbo Akademi University,Turku 20520,Finland.

出　　处：《Research》2025年第1期549-568,共20页研究(英文)

基　　金：supported by the National Natural Science Foundation Major International(Regional)Joint Research Program(grant number 82320108003);the National Natural Science Foundation of China(grant numbers 81970717 and 82170845);the National Key Research and Development Program of China(grant number 2021YFA1101800);the Key Research&Development Program of Jiangsu Province(grant number BE2022853);the Research Talent Cultivation Program of Zhongda Hospital Affiliated to Southeast University(grant number CZXM-GSP-RC28).

摘　　要：Islet transplantation has now become a promising treatment for insulin-deficient diabetes mellitus.Compared to traditional diabetes treatments,cell therapy can restore endogenous insulin supplementation,but its large-scale clinical application is impeded by donor shortages,immune rejection,and unsuitable transplantation sites.To overcome these challenges,an increasing number of studies have attempted to transplant hydrogel-encapsulated islet cells to treat diabetes.This review mainly focuses on the strategy of hydrogel-encapsulated pancreatic islet cells for diabetic cell therapy,including different cell sources encapsulated in hydrogels,encapsulation methods,hydrogel types,and a series of accessorial manners to improve transplantation outcomes.In addition,the formation and application challenges as well as prospects are also presented.

关 键 词：encapsulated pancreatic islet cells insulin deficient diabetes mellitus cell sources transplantation sites immune rejection islet transplantation donor shortages HYDROGEL 

分 类 号：R587.1[医药卫生—内分泌]