Swarming Magnetic Fe_(3)O_(4)@Polydopamine-Tannic Acid Nanorobots:Integrating Antibiotic-Free Superficial Photothermal and Deep Chemical Strategies for Targeted Bacterial Elimination  

作　　者：Luying Si Shuming Zhang Huiru Guo Wei Luo Yuqin Feng Xinkang Du Fangzhi Mou Huiru Ma Jianguo Guan 

机构地区：[1]State Key Laboratory of Advanced Technology for Materials Synthesis and Processing,International School of Materials Science and Engineering,Wuhan University of Technology,Wuhan,China [2]Wuhan Institute of Photochemistry and Technology,Wuhan,China [3]School of Chemistry,Chemical Engineering and Life Science,Wuhan University of Technology,Wuhan,China

出　　处：《Research》2025年第1期840-853,共14页研究(英文)

基　　金：supported by the National Key Research and Development Project(no.2021YFA1201400);the National Natural Science Foundation of China(no.52073222);the Innovation Team in Key Areas of the Innovation Talent Promotion Plan(2021)of MOST of China.

摘　　要：Micro/nanorobots(MNRs)are envisioned to provide revolutionary changes to therapies for infectious diseases as they can deliver various antibacterial agents or energies to many hard-to-reach infection sites.However,existing MNRs face substantial challenges in addressing complex infections that progress from superficial to deep tissues.Here,we develop swarming magnetic Fe3O4@polydopamine-tannic acid nanorobots(Fe3O4@PDA-TA NRs)capable of performing targeted bacteria elimination in complicated bacterial infections by integrating superficial photothermal and deep chemical strategies.The Fe3O4@PDA-TA nanoparticles(NPs),serving as building blocks of the nanorobots,are fabricated by in situ polymerization of dopamine followed by TA adhesion.When driven by alternating magnetic fields,Fe3O4@PDA-TA NPs can assemble into large energetic microswarms continuously flowing forward with tunable velocity.Thus,the swarming Fe3O4@PDA-TA NRs can be navigated to achieve rapid broad coverage of a targeted superficial area from a distance and rapidly eradicate bacteria residing there upon exposure to near-infrared(NIR)light due to their efficient photothermal conversion.Additionally,they can concentrate at deep infection sites by traversing through confined,narrow,and tortuous passages,exerting sustained antibacterial action through their surface TA-induced easy cell adhesion and subsequent membrane destruction.Therefore,the swarming Fe3O4@PDA-TA NRs show great potential for addressing complex superficial-to-deep infections.This study may inspire the development of future therapeutic microsystems for various diseases with multifunction synergies,task flexibility,and high efficiency.

关 键 词：therapies infectious diseases complex infections chemical therapy magnetic nanoparticles POLYDOPAMINE photothermal therapy targeted bacteria elimination tannic acid 

分 类 号：R318[医药卫生—生物医学工程]