Bioinspired Zwitterionic Block Polymer-Armored Nitric Oxide-Generating Coating Combats Thrombosis and Biofouling  

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作  者:Qing Ma Wentai Zhang Xiaohui Mou Nan Huang Haimang Wang Hongyu Zhang Zhilu Yang 

机构地区:[1]School of Materials Science and Engineering,Key Lab of Advanced Technology of Materials of Education Ministry,Southwest Jiaotong University,Chengdu,610031,China [2]Dongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine,The Tenth Affiliated Hospital,Southern Medical University,Dongguan,523059,China [3]GuangZhou Nanchuang Mount Everest Company for Medical Science and Technology,Guangzhou,510670,China [4]State Key Laboratory of Tribology in Advanced Equipment,Department of Mechanical Engineering,Tsinghua University,Beijing,100084,China [5]Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,352001 Zhejiang,China

出  处:《Research》2025年第1期870-884,共15页研究(英文)

基  金:supported by the National Natural Science Foundation of China(82072072,32261160372,52275199,32171326,and 32371377);Guang Dong Basic and Applied Basic Research Foundation(2022B1515130010 and 2021A1515111035);Wenzhou Science and Technology Major Project(Y2023138);Wenzhou Institute,University of Chinese Academy of Sciences startup fund(WIUCASQD2023013);Beijing-Tianjin-Hebei Fundamental Research Cooperation Project(J230001);Leading Talent Project of Guangzhou Development District(2020-L013);Dongguan Science and Technology of Social Development Program(20231800906311).

摘  要:Thrombosis and infection are 2 major complications associated with central venous catheters(CVCs),resulting in substantial mortality and morbidity.The concurrent long-term administration of antibiotics and anticoagulants to address these complications have been demonstrated to cause severe side effects such as antibiotic resistance and bleeding.To mitigate these complications with minimal or no drug utilization,we developed a bioinspired zwitterionic block polymer-armored nitric oxide(NO)-generating functional coating for surface modification of CVCs.This armor was fabricated by precoating with a Cu-dopamine(DA)/selenocysteamine(SeCA)(Cu-DA/SeCA)network film capable of catalytically generating NO on the CVCs surface,followed by grafting of a zwitterionic p(DMA-b-MPC-b-DMA)polymer brush.The synergistic effects of active attack by NO and copper ions provided by Cu-DA/SeCA network and passive defense by zwitterionic polymer brush imparted the CVCs surface with durable antimicrobial properties and marked inhibition of platelets and fibrinogen.The in vivo studies confirmed that the surface-armored CVCs could effectively reduce inflammation and inhibit thrombosis,indicating a promising potential for clinical applications.

关 键 词:BIOFOULING central venous catheters THROMBOSIS nitric oxide zwitterionic block polymer central venous catheters cvcs resulting antibiotic resistance bioinspired coating 

分 类 号:R318[医药卫生—生物医学工程]

 

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