A Structural Mimic of Carbonic Anhydrase in Zeolitic Imidazolate Frameworks via Trans-functionalization for Enhancing Hydrolytic Activity  

作　　者：Fanchen Meng Cheng Xu Linghai Zhang Xiaohan Huang Xinglong Zhang Wenlei Zhang Yongqi Luo Weina Zhang Wei Huang Fengwei Huo Suoying Zhang 

机构地区：[1]Key Laboratory of Flexible Electronics (KLOFE),Institute of Advanced Materials (IAM) & School of Flexible Electronics (Future Technologies),Nanjing Tech University,Nanjing 211816,P.R.China

出　　处：《Research》2025年第1期966-974,共9页研究(英文)

基　　金：supported by the National Natural Science Foundation of China(62288102,22305116,21908105,21727808,and 21971114);the Jiangsu Provincial Funds for Natural Science Foundation(BK20230308 and BK20200090).

摘　　要：Metal-organic frameworks(MOFs)have been widely considered as ideal platforms for the preparation of biomimetic catalysts,but it remains challenging to fabricate MOF-based enzyme-like catalysts with optimal activity.Here,we leverage the inherent flexibility of MOFs and propose a novel trans-functionalization strategy to construct a carbonic anhydrase(CA)mimic by the structural transformation from ZIF-L to ZIF-8.Theoretical and experimental results reveal that during the structural transformation,the hydroxyl group will preferentially coordinate with the interlayer Zn clusters to form the CA-like active center Zn-N3-OH.Therefore,more accessible active centers are generated on the as-prepared ZIF-8-OH,resulting in substantially enhanced catalytic activity in the hydrolysis of para-nitrophenyl acetate.

关 键 词：structural transformationthe biomimetic catalystsbut metal organic frameworks structural mimic carbonic anhydrase carbonic anhydrase ca mimic trans functionalization 

分 类 号：O64[理学—物理化学]