孟鲁司特钠联合布地奈德雾化吸入治疗儿童社区获得性肺炎的临床效果  

Clinical effect of Montelukast Sodium combined with Budesonide aerosol inhalation in the treatment of children with community-acquired pneumonia

作　　者：李妙菡 LI Miaohan(Department of Outpatient and Emergency,Huacheng Community Health Service Center in Huadu District,Guangzhou City,Guangdong Province,Guangzhou 510800,China)

机构地区：[1]广州市花都区花城社区卫生服务中心门急诊,广东广州510800

出　　处：《妇儿健康导刊》2025年第6期115-118,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的 分析孟鲁司特钠联合布地奈德雾化吸入治疗儿童社区获得性肺炎的临床效果。方法 选取2023年1月至2024年1月广州市花都区花城社区卫生服务中心收治的160例社区获得性肺炎患儿作为研究对象,按照随机数字表法分为对照组与观察组,每组各80例。对照组治疗方法为布地奈德雾化吸入,观察组治疗方法为孟鲁司特钠联合布地奈德雾化吸入。比较两组治疗总有效率、炎症因子水平、临床症状消失时间、不良反应总发生率。结果 和对照组比较,观察组治疗总有效率更高,差异有统计学意义(P<0.05)。治疗后,两组白细胞介素-6(IL-6)、降钙素原(PCT)、C反应蛋白(CPR)水平均较治疗前下降,且和对照组相比,观察组IL-6、PCT、CPR水平均更低(P<0.05)。观察组发热、咳嗽、喘息、肺部啰音消失时间均短于对照组(P <0.05)。两组不良反应总发生率比较无差异(P> 0.05)。结论 孟鲁司特钠联合布地奈德雾化吸入治疗儿童社区获得性肺炎的效果确切,能够有效缓解临床症状,减轻炎症反应,具备推广价值。Objective To analyze the clinical effect of Montelukast Sodium combined with Budesonide aerosol inhalation in the treatment of children with community-acquired pneumonia.Methods A total of 160 children with community-acquired pneumonia admitted to Huacheng Community Health Service Center in Huadu District,Guangzhou City from January 2023 to January 2024 were selected as the research objects.Using the random number table method,these children were divided into the observation group(n=80) and the control group(n=80).The control group received Budesonide aerosol inhalation treatment,while the observation group received Montelukast Sodium combined with Budesonide aerosol inhalation.The total effective rate of treatment,the levels of inflammatory factors,disappearance time of clinical symptoms,and total incidence of adverse reactions in the two groups were compared.Results Compared with the control group,the total effective rate of treatment in the observation group was higher,and the difference was statistically significant(P < 0.05).After treatment,the levels of interleukin-6(IL-6),procalcitonin(PCT),and C-reactive protein(CRP) in both groups decreased compared to those before treatment,and the levels of IL-6,PCT,and CPR in the observation group were lower than those in the control group(P < 0.05).The disappearance time of fever,cough,wheezing,and lung rales in the observation group was shorter than that in the control group(P <0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P > 0.05).Conclusion Montelukast Sodium combined with Budesonide aerosol inhalation has a definite effect in the treatment of children with community-acquired pneumonia,which can effectively alleviate clinical symptoms and reduce inflammatory reactions,and is worthy of clinical promotion.

关 键 词：孟鲁司特钠 布地奈德 儿童社区获得性肺炎 

分 类 号：R725.6[医药卫生—儿科]