妊娠高血压患者血清非对称性二甲基精氨酸、胰岛素样生长因子-1的表达及与妊娠结局的相关性  

Expression of serum asymmetric dimethyl arginine and insulin-like growth factor-1 in patients with gestational hypertension and their correlation with pregnancy outcomes

作　　者：韩向飞 HAN Xiangfei(Department of Laboratory Medicine,Beijing Changping District Maternal and Child Health Hospital,Beijing 102200,China)

机构地区：[1]北京市昌平区妇幼保健院检验科,北京102200

出　　处：《妇儿健康导刊》2025年第6期195-198,F0003,共5页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的探讨血清非对称性二甲基精氨酸(ADMA)、胰岛素样生长因子-1(IGF-1)在妊娠高血压(GH)患者中的表达水平,及相关指标对GH患者不良妊娠结局的预测价值。方法纳入北京市昌平区妇幼保健院2020年6月至2021年8月收治的300例GH患者,根据妊娠结局分为不良妊娠结局组、正常妊娠结局组。比较两组临床资料、孕中期ADMA、IGF-1表达水平;采用多因素logistic回归分析GH患者发生不良妊娠结局的影响因素,并采用受试者工作特征(ROC)曲线分析相关指标对GH患者妊娠结局的预测价值。结果300例GH患者中,56例发生不良妊娠结局,发生率为18.67%(56/300)。不良妊娠结局组孕中期血压、孕中期ADMA表达水平高于正常妊娠结局组,孕中期IGF-1表达水平低于正常妊娠结局组(P<0.05)。logistic回归分析结果显示,舒张压、ADMA和IGF-1是GH患者不良妊娠结局的影响因素(P<0.05)。ROC曲线结果显示,舒张压及ADMA、IGF-1预测GH患者妊娠结局的曲线下面积分别为0.640、0.791、0.880。结论孕中期舒张压及ADMA、IGF-1与GH患者不良妊娠结局有关,且具有一定的预测价值,其中IGF-1预测价值较高。Objective To investigate the expression of serum asymmetric dimethyl arginine(ADMA)and insulin-like growth factor-1(IGF-1)in patients with gestational hypertension(GH)and the predictive value of related indexes for adverse pregnancy outcomes in GH patients.Methods A total of 300 GH patients admitted to Beijing Changping District Maternal and Child Health Hospital from June 2020 to August 2021 were included,and divided into adverse pregnancy outcome group and normal pregnancy outcome group according to pregnancy outcome.The clinical data,expression levels of ADMA and IGF-1 in the second trimester were compared between the two groups.Multivariate logistic regression was used to analyze the influencing factors of adverse pregnancy outcomes in GH patients,and the predictive value of related indexes for pregnancy outcomes in GH patients was analyzed by receiver operating characteristic(ROC)curve.Results Among 300 GH patients,56 had adverse pregnancy outcomes,with an incidence of 18.67%(56/300).The blood pressure and the level of ADMA expression in the second trimester of the adverse pregnancy outcome group were higher than those in the normal pregnancy outcome group,and the level of IGF-1expression in the second trimester of the adverse pregnancy outcome group was lower than that of the normal pregnancy outcome group(P<0.05).The logistic regression analysis showed that diastolic blood pressure,ADMA and IGF-1 were the influential factors for adverse pregnancy outcomes in GH patients(P<0.05).The results of ROC curve showed that the area under the curve of diastolic blood pressure,ADMA and IGF-1 to predict pregnancy outcome in GH patients were 0.640,0.791 and 0.880,respectively.Conclusion Diastolic blood pressure,ADMA and IGF-1 in the second trimester are associated with adverse pregnancy outcomes in GH patients,and have certain predictive value,among which IGF-1 has a higher predictive value.

关 键 词：妊娠高血压 非对称性二甲基精氨酸 胰岛素样生长因子-1 预测价值 

分 类 号：R446[医药卫生—诊断学]