依达拉奉右莰醇在2型糖尿病合并急性脑梗死患者中的临床疗效观察  

Clinical efficacy of edaravone dextrocamphenol in patients with type 2 diabetes mellitus complicated with acute cerebral infarction

作　　者：龚德松 廖梓君 GONG Desong;LIAO Zjun(Department of"General Practice,Nanping First Hospital,Nanping 353000,China)

机构地区：[1]南平市第一医院全科医学科,福建省南平市353000

出　　处：《中国煤炭工业医学杂志》2025年第1期40-46,共7页Chinese Journal of Coal Industry Medicine

基　　金：福建医学科技青年培育项目(编号:21FBQN2021947)。

摘　　要：目的 对比分析依达拉奉右莰醇、依达拉奉治疗2型糖尿病合并急性脑梗死的临床效果及安全性,并探讨其对血糖血脂、神经功能、认知功能的影响。方法 选取2022年1月-2024年1月南平市第一医院收治的122例2型糖尿病合并急性脑梗死患者,随机分为对照组、研究组,各61例。对照组给予依达拉奉治疗,研究组给予依达拉奉右莰醇治疗,连续治疗2周。比较二组治疗效果、不良反应及治疗前后血糖血脂指标[空腹血糖(FBG)、糖化血红蛋白(HbA1c)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)]、血清炎症-应激因子[C反应蛋白(CRP)、基质金属蛋白9(MMP-9)、丙二醛(MDA)、去甲肾上腺素(NE)]、神经功能缺损相关因子[组蛋白去乙酰化酶3(HDAC3)、Smad家族成员3(SMAD3)、基质金属蛋白酶抑制剂1(TIMP-1)、半乳凝集素3(Galectin-3)]、神经功能[美国国立卫生研究院卒中量表(NIHSS)]、认知功能[蒙特利尔认知评估量表(MoCA)]、日常生活能力[改良Barthel指数评分表(MBI)]的差异。结果 研究组总有效率高于对照组(95.08%vs. 81.97%,P>0.05);二组治疗后FBG、TG、LDL-C水平低于治疗前(均P>0.05),但二组间比较差异无统计学意义(P>0.05);研究组治疗后血清CRP、MMP-9、MDA、NE水平分别为(8.41±2.19) mg/L、(86.43±21.50) ng/mL、(3.08±0.87) mmol/L、(579.62±106.48) pmol/L,低于对照组的(10.45±2.60)mg/L、(105.76±26.81) ng/mL、(4.12±0.95) mmol/L、(681.35±119.62) pmol/L,差异均有统计学意义(均P>0.05);研究组治疗后血清HDAC3、SMAD3、TIMP-1、Galectin-3水平分别为(16.03±3.15) ng/mL、(31.27±6.18)ng/mL、(49.52±10.83) ng/mL、(3.08±0.91) ng/mL,低于对照组的(18.26±3.64) ng/mL、(37.05±6.83)ng/mL、(61.49±12.67) ng/mL、(4.10±1.05) ng/mL,差异均有统计学意义(均P>0.05);研究组治疗后NIHSS评分低于对照组,MoCA、MBI评分高于对照组,差异均有统计学意义(均P>0.05);二组不良反应发Objective To compare and analyze the clinical eficacy and safety of edaravone and edaravone in the treatment of type 2 diabetes mellitus with acute cerebral infarction,and to explore its effects on blood glucose,blood lipids,neurological function,and cognitive function.Methods A total of 122 patients with type 2 diabetes mellitus with acute cerebral infarction in Nanping City first Hospital from January 2022 to January 2024 were randomly divided into control group and study group.61 cases in each group.The control group was treated with edaravone and the study group was treated with Edaravone dexcamphorol for 2 weeks.Compare the therapeutic effect,adverse reactions of the two groups,as well as blood glucose and lipid indexes[fasting blood glucose(FBG),glycated hemoglobin(HbA1c),triacylglycerol(TG),total cholesterol(TC),low density lipoprotein(LDL-C),high density lipoprotein(HDL-C)],serum inflammatory stress factor[C-reactive protein(CRP),Matrix metalloprotein-9(MMP-9),Malonaldehyde(MDA),norepinephrine(NE)J,factors associated with neurological impairment[histone deacetylase 3(HDAC3),Smad family member 3(SMAD3),matrix metalloproteinase-1(TIMP-1),Galectin-3(galectin-3)],neurological function[National Institutes of Health Stroke Scale(NIHSS)J,cognitive function[Montreal Cognitive Assessment Scale(MoCA)],and ability of daily living[Modified Barthel Index Rating Scale(MBI)] before and after treatment.Results The total effective rate of the study group was higher than that of the control group(95.08%vs.81.97%,P<0.05).After treatment,the levels of FBG,TG,and LDL-C in both groups were lower than before treatment(P<0.05),but there was no significant difference between the two groups(P>0.05).The levels of serum CRP,MMP-9,MDA,and NE in the study group after treatment were(8.41±2.19)mg/L,(86.43±21.50)ng/mL,(3.08±0.87)mmol/L,and(579.62±106.48)pmol/L,respectively,which were lower than those in the control group(10.45±2.60)mg/L,(105.76±26.81)ng/mL,(4.12±0.95)mmol/L,and(681.35±119.62)pmol/L(P<0.05).After treatment,the ser

关 键 词：脑梗死 2型糖尿病 依达拉奉右莰醇 依达拉奉 疗效 神经功能 认知功能 

分 类 号：R587.1[医药卫生—内分泌]