血速升颗粒联合促红细胞生成素对慢性肾衰竭肾性贫血治疗靶目标、血清学指标的影响  

Effects of Xuesusheng Granules combined with erythropoietin on the treatment target and serological indicators of renal anemia in chronic renal failure

作　　者：宫磊[1] 高江彦[2] 魏红叶 王亚妮 王国卫[5] 石良静 GONG Lei;GAO Jjiangyan;WEI Hongye;WANG Yani;WANG Guowei;SHI Liangjing(Department of Nephrology,Hebei Chest Hospital,Shijiazhuang 050041;Department of Oncology,Hebei Chest Hospital,Shijiazhuang 050041;Department of Cardiology,Hebei Chest Hospital,Shijiazhuang 050041;Hebei Chest Hospital Molecular Laboratory,Shijiazhuang 050041;Hebei Chest Hospital Department of Traditional Chinese Medicine Shijiazhuang 050041,China)

机构地区：[1]河北省胸科医院肾内科,河北省石家庄市050041 [2]河北省胸科医院肿瘤科,河北省石家庄市050041 [3]河北省胸科医院心内科,河北省石家庄市050041 [4]河北省胸科医院分子实验室,河北省石家庄市050041 [5]河北省胸科医院中医科,河北省石家庄市050041

出　　处：《中国煤炭工业医学杂志》2025年第1期47-55,共9页Chinese Journal of Coal Industry Medicine

基　　金：河北省中医药管理局2019年度中医药类科研计划课题(编号:2019101)。

摘　　要：目的 探讨血速升颗粒联合促红细胞生成素对慢性肾衰竭肾性贫血治疗靶目标、贫血相关指标、肾功能指标、临床症状的影响。方法 选取2021年1月-2023年6月河北省胸科医院肾内科肾性贫血患者106例,按照随机数字表法分为两组,每组各53例。两组均给予基础治疗(支持治疗、补充铁剂、叶酸、维生素B12),在此基础上,对照组给予促红细胞生成素,观察组给予血速升颗粒联合促红细胞生成素治疗。比较两组达到靶目标时间、不良反应、治疗效果及治疗前、治疗2周、4周、6周贫血临床症状(面色苍白、倦怠乏力、食少纳差、心悸头晕)评分、贫血相关指标[血红蛋白(Hb)、红细胞比容(HCT)、红细胞计数(RBC)、铁蛋白(SF)]、炎性因子[白介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)]、肾功能指标[血肌酐(Scr)、血尿素氮(BUN)]。结果 观察组达到靶目标时间(6.27±1.16)周,短于对照组(8.09±1.71)周,差异有统计学意义(t=6.412,P<0.001);观察组总有效率94.34%(50/53),高于对照组81.13%(43/53),差异有统计学意义(χ^(2)=4.296,P=0.038);治疗2周后观察组面色苍白评分(3.11±0.34)分、食少纳差评分(3.13±0.44)分、倦怠乏力评分(3.24±0.40)分、心悸头晕评分(3.05±0.37)分均低于对照组(3.48±0.31)分、(3.53±0.34)分、(3.67±0.35)分、(3.48±0.32)分(t值分别为5.854、5.237、5.890、6.399,均P<0.001);治疗4周后观察组面色苍白评分(2.26±0.21)分、食少纳差评分(2.17±0.31)分、倦怠乏力评分(2.42±0.24)分、心悸头晕评分(2.27±0.32)分均低于对照组(2.65±0.23)分、(2.59±0.20)分、(2.88±0.33)分、(2.71±0.28)分(t值分别为9.116、8.288、8.207、7.533,均P<0.001);治疗6周后观察组面色苍白评分(1.73±0.18)分、食少纳差评分(1.55±0.25)分、倦怠乏力评分(2.06±0.19)分、心悸头晕评分(1.81±0.21)分均低于对照组(2.03±0.20)分、(1.94±0.16)分、(2.35±0.23)分、(2.10±0.21)�Objective To explore the effects of Xuesusheng Granules combined with erythropoietin on the treatment target,anemia-related indicators,renal function indicators,and clinical symptoms of renal anemia in chronic renal failure.Methods A total of 106 patients with renal anemia in the Department of Nephrology of Hebei Provincial Chest Hospital from January 2021 to June 2023 were selected and randomly divided into two groups according to a random number table,with 53 cases in each group.Both groups were given basic treatment(supportive treatment,supplementation of iron,folic acid,vitamin B12).On this basis,the control group was given erythropoietin,and the observation group was given Xueshuisheng Granules combined with erythropoietin.The time to reach the target goal,adverse reactions and the therapeutic effect were compared between the two groups,as well as clinical symptoms of anemia(pallor,fatigue,lack of appetite,palpitations and dizziness)scores,anemia-related indicators(hemoglobin(Hb),hematocrit(HCT),red blood cell count(RBC),ferritin(SF),inflammatory factors(interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)),renal function indicators(serum creatinine(Scr),blood urea nitrogen(BUN)before treatment,2 weeks,4 weeks,and 6 weeks after treatment.Results The target time for the observation group was(6.27±1.16)weeks,which was shorter than the control group's(8.09±1.71)weeks,and the difference was statistically significant(t=6.412,P<0.001).The total effective rate of the observation group was 94.34%(50/53),which was higher than that of the control group(81.13%,43/53),and the difference was statistically significant(x^(2)=4.296,P=0.038).After 2 weeks of treatment,the observation group had lower scores for pale complexion(3.11±0.34)scores,poor appetite and poor digestion(3.13±0.44)scores,fatigue and weakness(3.24±0.40)scores,and palpitations and dizziness(3.05±0.37)scores than the control group(3.48±0.31)scores,(3.53±0.34)scores,(3.67±0.35)scores,and(3.48±0.32)scores(

关 键 词：血速升颗粒 促红细胞生成素 肾性贫血 靶目标 肾功能 临床症状 

分 类 号：R692.5[医药卫生—泌尿科学]