2021-2023年苏州市5岁以下儿童感染性腹泻病原学及流行特征分析  

Etiology and epidemic characteristics of infectious diarrhea in children under 5 years of age in Suzhou from 2021 to 2023

作　　者：包林[1] 王笛 朱莉勤 陈立凌[1] Bao Lin;Wang Di;Zhu Liqin;Chen Liling(Department for Infectious Disease Control and Prevention,Suzhou Center for Disease Control and Prevention,Suzhou 215006;Department for Microbiological experiment,Suzhou Center for Disease Control and Prevention,Suzhou 215006)

机构地区：[1]苏州市疾病预防控制中心传染病防制科,215008 [2]苏州市疾病预防控制中心微生物检验科,215008

出　　处：《国际病毒学杂志》2025年第1期67-71,共5页International Journal of Virology

基　　金：苏州市科技发展计划项目(2022SS14)。

摘　　要：目的了解苏州市儿童感染性腹泻病原谱变化和流行特征,为精准防控提供依据。方法2021—2023年在苏州市某国家级哨点监测医院开展5岁以下腹泻住院儿童病原学监测,对病例完成流行病学调查,分析流行特征,采集所有病例粪便标本进行5种病毒和6类细菌检测和分型(群),分析病原谱变化情况。结果共纳入感染性腹泻病例935例,病原总检出率为47.17%,病毒检出率为43.21%,细菌检出率为6.52%。检出率排前三位的病原体是诺如病毒(20.64%)、轮状病毒(13.37%)和肠道腺病毒(8.66%),在新冠疫情不同时期主要病原检出率发生变化,诺如病毒取代轮状病毒成为优势病原体,腺病毒检出率明显上升。感染性腹泻在春季、秋季和冬季高发,7~36月龄是高发人群。结论2021—2023年苏州地区5岁以下儿童感染性腹泻主要由病毒引起,2021—2023年期间病原谱发生了变化,可能与新冠疫情影响有关。感染性腹泻具有明显的人群分布和季节性特征。需关注腺病毒引起重症的可能。Objective To understand the pathogenic spectrum and epidemic characteristics of infectious diarrhea in children in Suzhou city,and to provide evidence for accurate prevention and control.MethodsActive surveillance of infectious diarrhea pathogens was carried out in a national sentinel surveillance hospital in Suzhou from 2021 to 2023,epidemiological investigation of cases was completed,epidemic characteristics were analyzed,and fecal samples of all cases were collected for detection and classification of 5 viruses and 6 types of bacteria,and pathogen spectrum changes were analyzed.ResultsA total of 935 cases of infectious diarrhea were included,with the total pathogen detection rate of 47.17%,virus detection rate of 43.21%and bacteria detection rate of 6.52%.The top three pathogens in the detection rate were norovirus(20.64%),Rotavirus(13.37%)and intestinal adenovirus(8.66%).The detection rate of major pathogens changed in different periods of COVID-19 epidemic,and norovirus replaced rotavirus as the dominant pathogen,and the detection rate of intestinal adenovirus increased significantly.Infectious diarrhea occurs most frequently in spring,autumn and winter,and is most common in people aged 7-36 months.ConclusionsInfectious diarrhea in children under 5 years old in Suzhou from 2021 to 2023 is mainly caused by viruses,and the pathogen spectrum has changed significantly under the influence of the novel coronavirus epidemic.Infectious diarrhea has obvious population distribution and seasonal characteristics.Attention should be paid to the possibility of adenovirus causing severe illness.

关 键 词：儿童 感染性腹泻 病原学 腺病毒 

分 类 号：S85[农业科学—兽医学]