扫白茴风丸联合窄谱中波紫外线照射治疗阳虚血瘀型白癜风的疗效分析  

Therapeutic effect of Saobai Huifeng Pill combined with narrow-band ultraviolet B irradia⁃tion on vitiligo with yang deficiency and blood stasis

作　　者：李慧[1] 王绍莹 陆振华 李阳光 王远红[4] LI Hui;WANG Shao-ying;LU Zheng-hua;LI Yang-guang;WANG Yuan-hong(Heilongjiang University of Chinese Medicine,Harbin 150040,China;Guangming District Hospital of Shenz-hen,Shenzhen 518106,China;Heilongjiang Academy of Traditional Chinese Medicine,Harbin 150040,China;First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]深圳市光明区人民医院,广东深圳518106 [3]黑龙江省中医药科学院,黑龙江哈尔滨150040 [4]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《时珍国医国药》2025年第4期687-691,共5页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金面上项目(81873312);黑龙江省自然科学基金面上项目(LH2022H077)。

摘　　要：目的探讨扫白茴风丸联合窄谱中波紫外线(NB-UVB)照射在治疗阳虚血瘀型白癜风患者中的应用疗效。方法选取120例符合阳虚血瘀型的白癜风患者,随机分为观察组和对照组各60例,对照组接受NB-UVB照射治疗,观察组在对照组基础上口服扫白茴风丸,均持续治疗3个月。比较两组患者治疗效果,临床指标,治疗前后免疫指标、炎症因子和生活质量变化,以及治疗期间不良反应发生情况。结果治疗3个月后,观察组总有效率为93.33%,对照组为80.00%。观察组平均皮损面积较对照组小,平均复色面积较对照组大,面部(额、眼、颊、口鼻)平均复色时间均较对照组短。观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平较对照组高,白细胞介素-6和白细胞介素-8较对照组低,差异有统计学意义(P<0.05)。观察组参与限制、耻辱感和行为评分均较对照组低,差异有统计学意义(P<0.05)。结论扫白茴风丸联合NB-UVB照射治疗有效改善阳虚血瘀型白癜风患者临床症状,减少患者的皮损面积,提高生活质量,显著改善患者免疫炎症指标的表达水平。Objective To evaluate the therapeutic efficacy of Saobai Huifeng Pill(SBHFP)combined with narrow-band ultraviolet B(NB-UVB)irradiation in vitiligo patients with yang deficiency and blood stasis syndrome.Methods A total of 120 vitiligo patients di⁃agnosed with yang deficiency and blood stasis who met the inclusion criteria were randomly divided into the treatment group and the con⁃trol group,with 60 patients in each group.The control group received NB-UVB irradiation alone,while the observation group orally took SBHFP in addition to NB-UVB irradiation.Both groups underwent treatment for three months.Treatment outcomes,clinical indi⁃cators,immune and inflammatory markers before and after treatment,quality of life,and incidence of adverse events during treatment were compared between the two groups.Results After three months of treatment,the overall effective rate was 93.33%in the treatment group,compared to 80.00%in the control group.Patients in the treatment group demonstrated significantly smaller mean lesion areas,larger mean repigmentation areas,and shorter mean facial repigmentation times(involving the forehead,eyes,cheeks,and perioral re⁃gion)compared to the control group.Furthermore,levels of CD3^(+),CD4^(+),and the CD4^(+)/CD8^(+)ratio were significantly higher in the treatment group,while interleukin-6(IL-6)and interleukin-8(IL-8)levels were significantly lower than in the control group(P<0.05).Scores related to participation restriction,stigma,and behavior were also significantly lower in the treatment group,indicating improved quality of life(P<0.05).Conclusion The combination of SBHFP with NB-UVB irradiation demonstrated enhanced efficacy in alleviating clinical symptoms,reducing lesion areas,and promoting repigmentation in vitiligo patients with yang deficiency and blood stasis syndrome.This combined treatment also improved quality of life and favorably modulated immune and inflammatory markers,sug⁃gesting it may be a valuable therapeutic approach for this type of vitiligo patients.

关 键 词：扫白茴风丸 窄谱中波紫外线 阳虚血瘀型 白癜风 

分 类 号：R275.9[医药卫生—中西医结合]