血清尿酸水平与支气管哮喘关系的meta分析  

Meta-analysis of the relationship between serum uric acid level and bronchial asthma

作　　者：李莉 朱东平 陈璐 陆孝灵 夏应婷 冷静 LI Li;ZHU Dongping;CHEN Lu;LU Xiaoling;XIA Yingting;LENG Jing(College of Clinical Medicine,Dali University,Yunan,Dali 671000,China;Department of Respiratory and Critical Care Medicine,the Third People’s Hospital of Yunnan Province,Yunan,Kunming 650011,China)

机构地区：[1]大理大学临床医学院,云南大理671000 [2]云南省第三人民医院呼吸与危重症医学科,云南昆明650011

出　　处：《中国医药科学》2025年第5期72-75,共4页China Medicine And Pharmacy

摘　　要：目的探讨血清尿酸水平与支气管哮喘的关系,为相关治疗提供参考价值。方法计算机检索PubMed、Embase、Web of Science及CNKI数据库发表的血清尿酸水平与支气管哮喘相关研究,采用Review Manager 5.4及Stata 12.0软件进行meta分析。结果共纳入9项研究,共1053例哮喘患者和876例健康对照。结果显示,哮喘患者血清尿酸水平高于健康对照组[WMD=64.22,95%CI(3.75,124.68),P=0.04]。进行亚组分析发现<18岁哮喘人群血清尿酸水平较平均水平高。血清尿酸水平与哮喘严重程度有关[轻度vs.中重度:WMD=-81.37,95%CI(-138.82,-23.92),P=0.006]。急性发作期的血清尿酸水平相对于慢性持续期更高[WMD=149.25,95%CI(107.87,190.63),P<0.01]。结论血清尿酸水平与哮喘有关,血清中尿酸的水平越高,哮喘严重程度越明显,且急性发作期尿酸水平高于慢性持续期。Objective To explore the relationship between serum uric acid level and bronchial asthma,and to provide reference value for related treatment.Methods The research on the relationship between serum uric acid level and bronchial asthma published in PubMed,Embase,Web of Science and CNKI databases was searched by computer,and the meta-analysis was conducted by using Review Manager 5.4 and Stata 12.0 software.Results 9 studies were included,including 1053 asthma patients and 876 healthy controls.The results showed that the serum uric acid level of asthma patients was higher than that of healthy controls(WMD=64.22,95%CI[3.75,124.68],P=0.04).Subgroup analysis showed that the serum uric acid level of asthmatic people under 18 years old was higher than the average level.Serum uric acid level was related to the severity of asthma(mild vs.moderate severity:WMD=-81.37,95%CI[-138.82,-23.92],P=0.006).The level of serum uric acid in acute episode was higher than that in chronic duration(WMD=149.25,95%CI[107.87,190.63],P<0.01).Conclusion Serum uric acid level is related to asthma.The higher the serum uric acid level,the more obvious the severity of asthma and the uric acid level in acute attack is higher than that in chro nic duration.

关 键 词：哮喘 尿酸 哮喘严重程度 META分析 

分 类 号：R562.25[医药卫生—呼吸系统]