阿芬太尼联合苯磺酸瑞马唑仑在宫腔镜手术中的应用研究  

Application research of fentanyl combined with remimazolam besylate in hysteroscopy surgery

作　　者：蔡广雄 唐斌[1] CAI Guangxiong;TANG Bin(Key Laboratory of Anesthesia and Perioperative Neuroprotection of Liuzhou City,Department of Anesthesiology,Liuzhou Workers’Hospital,the Fourth Affiliated Hospital of Guangxi Medical University,Guangxi,Liuzhou 545005,China)

机构地区：[1]广西医科大学第四附属医院柳州市工人医院麻醉科、广西壮族自治区柳州市麻醉与围术期神经保护重点实验室,广西柳州545005

出　　处：《中国医药科学》2025年第5期159-162,共4页China Medicine And Pharmacy

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(Z20211211)。

摘　　要：目的探讨在宫腔镜手术中应用阿芬太尼与苯磺酸瑞马唑仑组合的效能。方法选取2021年1月至2023年12月在广西医科大学第四附属医院柳州市工人医院进行宫腔镜手术,并使用阿芬太尼与苯磺酸瑞马唑仑进行麻醉的50例患者作为观察组;通过倾向性配对,另选取同期接受相同手术并以阿芬太尼加丙泊酚麻醉的50例患者作为对照组。对两组患者的资料进行回顾性评估,比较两组在麻醉诱导前、睫毛反射消失时及扩张宫颈时3个时刻的平均动脉血压、心率、呼吸频率与血氧饱和度,评估两组在术后6、12及24 h的疼痛程度及Ramsay镇静评分,比较两组围手术期相关指标(麻醉起效时间、手术持续时间、呼吸恢复时间)。结果两组患者在麻醉开始前、睫毛反射消失时及扩张宫颈时3个时刻的平均动脉血压、心率、呼吸频率与血氧饱和度比较,差异无统计学意义(P>0.05)。观察组在术后6、12及24 h的视觉模拟评分法评分显著低于对照组,差异有统计学意义(P<0.05)。两组患者在术后各时段的Ramsay镇静评分比较,差异无统计学意义(P>0.05)。两组患者手术持续时间比较,差异无统计学意义(P>0.05)。观察组麻醉起效时间、呼吸恢复时间明显短于对照组,差异有统计学意义(P<0.05)。结论宫腔镜手术中运用阿芬太尼与苯磺酸瑞马唑仑的联合方案,效果较满意,建议在实践中推广应用。Objective To investigate the efficacy of the combination of fentanyl and remazolam besylate in hysteroscopy surgery.Methods Patients who underwent hysteroscopy surgery at Liuzhou Workers’Hospital of the Fourth Affiliated Hospital of Guangxi Medical University from January 2021 to December 2023 were selected and divided into the observation group(n=50,anesthetized with fentanyl and remazolam besylate).By propensity pairing,patients who underwent the same surgery simultaneously were selected and divided into the control group(n=50,anesthetized with fentanyl and propofol).The data of two groups of patients were retrospectively evaluated.The average arterial blood pressure,heart rate,respiratory rate,and blood oxygen saturation between two groups at 3 time points before anesthesia,disappearance of eyelash reflex,and cervical dilation were compared.The pain levels and Ramsay sedation scores of two groups at 6,12,and 24 hours after surgery were evaluated.Two related perioperative indices(anesthesia onset time,operative duration,and respiratory recovery time)were compared.Results There were no statistically significant differences in the average arterial blood pressure,heart rate,respiratory rate,and blood oxygen saturation between the two groups of patients at 3-time points before anesthesia,disappearance of eyelash reflex,and cervical dilation(P>0.05).The visual analogue scale of the observation group was significantly lower than that of the control group at 6,12,and 24 hours after surgery,with statistically significant difference(P<0.05).There was no statistically significant difference in Ramsay sedation score between the two groups of patients at different postoperative time points(P>0.05).There was no statistically significant difference in the operative duration between the two groups(P>0.05).The onset time of anesthesia and respiratory recovery time in the observation group were significantly shorter than those in the control group,with statistically significant differences(P<0.05).Conclusion The combination t

关 键 词：阿芬太尼 苯磺酸瑞马唑仑 宫腔镜 丙泊酚 麻醉诱导 

分 类 号：R614[医药卫生—麻醉学]