化浊解毒法治疗流行性感冒临床研究  

Efficacy of therapy for resolving turbidity and removing toxin on influenza

作　　者：李亚云 高天慈 张玮超 乔雅婷 梅建强 陈分乔 LI Yayun;GAO Tianci;ZHANG Weichao;QIAO Yating;MEI Jianqiang;CHEN Fenqiao(Graduate School of Hebei University of Traditional Chinese Medicine,Shijiazhuang 050091,Hebei,China;The First Hospital Affiliated to Hebei University of Traditional Chinese Medicine,Shijiazhuang 050011,Hebei,China)

机构地区：[1]河北中医药大学研究生学院,河北石家庄050091 [2]河北中医药大学附属第一医院,河北石家庄050011

出　　处：《现代中西医结合杂志》2025年第4期479-484,共6页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：河北省中医药管理局科研计划项目(2022025);第五批全国中医临床优秀人才研修项目(国中医药人教函〔2022〕1号);2022年全国名老中医专家传承工作室建设项目(国中医药人教函〔2022〕75号);第二届全国名中医传承工作室建设项目(国中医药办人教函〔2022〕245号)。

摘　　要：目的观察香苏化浊颗粒联合磷酸奥司他韦治疗成人流行性感冒的临床疗效。方法选取2022年1月—2024年1月就诊于河北省中医院急诊科的76例流行性感冒患者,按照随机数字表法,根据就诊顺序将受试患者随机分为对照组和治疗组,每组38例。对照组给予磷酸奥司他韦胶囊治疗,治疗组在对照组基础上加服香苏化浊颗粒,2组均治疗5 d。观察比较2组患者治疗前后中医证候评分、血常规[白细胞计数(WBC)、淋巴细胞百分比(LYM%)]及炎症因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)]水平,记录2组退热时间、退热起效时间,计算不同时间点退热率、病毒抗原转阴率,评估2组临床疗效,并记录治疗过程中不良反应发生情况。结果2组患者治疗5 d后中医证候评分、LYM%及血清CRP、IL-6、TNF-α、IFN-γ水平均较治疗前明显降低(P均<0.05),且治疗组中医证候评分及血清CRP、IL-6、TNF-α、IFN-γ水平均明显低于对照组(P均<0.05);治疗组退热时间、退热起效时间均明显短于对照组(P均<0.05);治疗组治疗24 h、48 h和72 h的退热率分别为54.1%(20/37)、91.9%(34/37)和100%(37/37),对照组治疗24 h、48 h和72 h的退热率分别为30.6%(11/36)、69.4%(25/36)和91.7%(33/36),治疗组治疗24 h和48 h退热率均明显高于对照组(P均<0.05),2组治疗72 h退热率比较差异无统计学意义(P>0.05)。治疗5 d后,治疗组病毒抗原转阴率为97.3%(36/37),对照组为83.3%(30/36),治疗组转阴率明显高于对照组(P<0.05);治疗组愈显率和总有效率分别为64.9%(24/37)和94.6%(35/37),对照组分别为38.9%(14/36)和77.8%(28/36),治疗组愈显率和总有效率均明显高于对照组(P均<0.05)。2组均未发生明显不良反应。结论香苏化浊颗粒联合磷酸奥司他韦治疗流行性感冒疗效显著,尤其是在改善症状,降低血清炎症因子水平,缩短退热时间和退热起效时间以及退热率方面较�Objective It is to observe the clinical efficacy of Xiangsu Granules for resolving turbidity combined with oseltamivir phosphate in the treatment of adult influenza.Methods Seventy-six patients with influenza who visited the Emergency Department of Hebei Provincial Hospital of Traditional Chinese Medicine from January 2022 to January 2024 were selected and randomly divided into control group and treatment group according to their visit order by randomized numerical table,with 38 cases in each group.The control group was treated with oseltamivir phosphate capsules,and the treatment group was treated with Xiangsu Granules for resolving turbidity combined with oseltamivir phosphate,both groups were treated for 5 days.The TCM syndrome scores,levels of blood routine[white blood cell counts(WBC),lymphocyte percentage(LYM%)],and inflammatory factors such as C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and interferon-γ(IFN-γ)of patients in the two groups were observed and compared before and after treatment,and the antipyretic time,antipyretic onset time,antipyretic rate at different time points,negative conversion rate of viral antigen of the two groups were recorded or calculated,and the clinical efficacy as well as the incidence of adverse reactions during treatment of the two groups were assessed or recorded.Results After 5 days of treatment,the TCM syndrome score,LYM%and serum levels of CRP,IL-6,TNF-αand IFN-γof patients in the two groups were significantly lower than those before treatment(all P<0.05),and the TCM syndrome score,serum levels of CRP,IL-6,TNF-αand IFN-γof patients in the treatment group were significantly lower than those in the control group(all P<0.05);the antipyretic time,antipyretic onset time of the treatment group were significantly shorter than those of the control group(both P<0.05);the antipyretic rate rates after treatment for 2 hours,48 hours and 72 hours of the treatment group were 54.1%(20/37),91.9%(34/37)and 100%(37/37),respectively,and those after t

关 键 词：流行性感冒 香苏化浊颗粒 化浊解毒 磷酸奥司他韦 

分 类 号：R511.7[医药卫生—内科学]