噬菌体与细菌生物膜相互作用的研究进展  

Research Progress in the Interactions Between Bacteriophages and Bacterial Biofilms

作　　者：万启旸 包红朵[1] 张辉[1] 朱树娇 王冉[1] 周艳[1] WAN Qiyang;BAO Hongduo;ZHANG Hui;ZHU Shujiao;WANG Ran;ZHOU Yan(Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base,Ministry of Science and Technology,Institute of Food Safety and Nutrition,Jiangsu Academy of Agricultural Sciences,Nanjing 210014,China)

机构地区：[1]江苏省农业科学院农产品质量安全与营养研究所江苏省食品质量安全重点实验室-省部共建国家重点实验室培育基地,南京210014

出　　处：《中国动物传染病学报》2025年第1期218-227,共10页Chinese Journal of Animal Infectious Diseases

基　　金：国家自然科学基金(31972764)。

摘　　要：细菌生物膜是由多个细菌组成的群落结构,发挥着抵御外界恶劣环境的作用。研究发现细菌生物膜是细菌产生耐药性的重要原因之一,给食品和医疗等行业带来巨大的经济损失。而噬菌体作为能够感染并裂解细菌的病毒,可以有效抑制并清除细菌生物膜。近年来研究表明噬菌体还能够促进细菌生物膜的形成,因此噬菌体与细菌生物膜的相互作用仍需要深入研究。本文综述了目前关于噬菌体和细菌生物膜的相互作用研究所取得的重要进展,包括作用机制、影响因素,以及噬菌体防控细菌生物膜形成的潜力等,为应用噬菌体有效遏制细菌危害提供理论依据。Bacterial biofilms are community structures composed of multiple bacteria and play a role in resisting the harsh external environment.Previous studies have demonstrated that bacterial biofilms cause antibiotic resistance,which leads to huge economic losses in the food and medical industries.Bacteriophages(phages)are viruses that infect and lyse bacteria,thus effectively inhibit and eradicate bacterial biofilms.Nonetheless,it has been also revealed that phages promote biofilms formation.Therefore,the interactions between phages and bacterial biofilms need to be further deeply studied.Here,we reviewed the current progress of the interactions between phages and bacterial biofilms,including the mechanisms,infl uencing factors and application potentials of phages for controlling bacterial biofilm formation.We hoped that this summary would provide theoretical basis for phages to effectively prevent and control bacterial harms.

关 键 词：噬菌体 细菌生物膜 抗菌 噬菌体应用 

分 类 号：Q939.48[生物学—微生物学]