基于线粒体功能障碍探讨应用脏腑气化理论诊疗慢性呼吸系统疾病的生物学基础  

Study on the Biological Basis of Applying "Visceral Qi Transformation" in Diagnosis and Treatment of Chronic Respiratory Diseases Based on Mitochondrial Dysfunction

作　　者：王玺 郭思佳[2] WANG Xi;GUO Sijia(Tianjin University of Traditional Chinese Medicine,Tianjin,China,301617;The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin,China,300250)

机构地区：[1]天津中医药大学,天津301617 [2]天津中医药大学第二附属医院,天津300250

出　　处：《河南中医》2025年第4期496-500,共5页Henan Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81874398,81403222);科技部国际科技合作与交流专项项目(2011DFA32750)。

摘　　要：现代医学之线粒体与中医之气均参与精微物质的转化并为人体生命活动提供动力,线粒体功能与中医阳气功能相似,线粒体调控人体代谢与脏腑气化功能类似,线粒体动力学与肾精的作用类似。慢性呼吸系统疾病中医病机为脏腑气机失调,气化失司,西医病理机制为线粒体功能障碍,导致氧化应激、炎症因子激活、线粒体过度融合和分裂缺陷及线粒体生物合成障碍等。宣白承气汤、益气温阳护卫汤以及黄芪甲苷、连翘脂素、延龄草皂苷和南五味子等在调节脏腑气化功能的同时,也可改善机体线粒体功能,为慢性呼吸系统疾病间的异病同治提供依据,也为中医气化相关理论的研究提供了生物学基础。Mitochondria in modern medicine and qi in TCM both participate in the transformation of essential substances and provide energy for human vital activities.Mitochondrial energy supply resembles the functional characteristics of yang qi in TCM,while mitochondrial regulation of metabolism parallels the mechanism of visceral qi movement and transformation.Furthermore,mitochondrial dynamics share functional similarities with the role of kidney essence in TCM.The pathogenesis of chronic respiratory diseases in TCM theory involves dysfunction of visceral qi movement and impaired qi transformation,whereas the Western medical pathological mechanism centers on mitochondrial dysfunction,leading to oxidative stress,activation of inflammatory factors,excessive mitochondrial fusion and fission defects,as well as mitochondrial biosynthesis disorders,etc.Notably,interventions such as Lung-Ventilating Purgative Decoction,Qi-Replenishing and Yang-Warming and Defense-Protecting Decoction as well as bioactive compounds including astragaloside IV,forsythiaside,trillin,and schisandrin,have demonstrated dual effects:regulating visceral qi transformation while improving mitochondrial function.These findings provide evidence for the TCM principle of "treating different diseases with the same method" in chronic respiratory diseases and establish a biological foundation for research on related TCM qi transformation theory.

关 键 词：慢性呼吸系统疾病 脏腑气化 线粒体 阳气 气机 气化 肾精 异病同治 

分 类 号：R256.1[医药卫生—中医内科学]