加味银翘汤治疗成人甲型流行性感冒风热夹湿证队列研究  

A Cohort Study on Modified Lonicera and Forsythia Decoction in the Treatment of Adult Influenza A Having Wind-Heat with Dampness Syndrome

作　　者：苏日娜 赵晶敏 张思涵 赵启亮[1,2] 张慧琪 常力[1,2] 刘凯 尹延重[1,2] 刘奉云 杜晶辉[2] 刘旻 孙宏源 孙昕 李桂伟 SU Rina;ZHAO Jingmin;ZHANG Sihan;ZHAO Qiliang;ZHANG Huiqi;CHANG Li;LIU Kai;YIN Yanzhong;LIU Fengyun;DU Jinghui;LIU Min;SUN Hongyuan;SUN Xin;LI Guiwei(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin,China,300381;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin,China,300381;Tianjin University of Traditional Chinese Medicine,Tianjin,China,301617;Tianjin People′s Hospital,Tianjin,China,300000)

机构地区：[1]天津中医药大学第一附属医院,天津300381 [2]国家中医针灸临床医学研究中心,天津300381 [3]天津中医药大学,天津301617 [4]天津市人民医院,天津300000

出　　处：《河南中医》2025年第4期544-548,共5页Henan Traditional Chinese Medicine

基　　金：国家重点研发计划课题项目(2018YFC1707503);天津市卫生健康科技人才培育项目(KJ20205);天津中医药大学教育教学改革研究项目(2023YJY036)。

摘　　要：目的:观察加味银翘汤治疗成人甲型流行性感冒风热夹湿证的有效性和安全性。方法:采用单中心、前瞻性、队列研究试验设计,以甲型流行性感冒风热夹湿证患者为研究对象,设双暴露因素(加味银翘汤、磷酸奥司他韦胶囊),分中药组、西药组和中西医联合组3组,中药组采用加味银翘汤治疗,西药组采用磷酸奥司他韦胶囊治疗,中西医联合组在西药组基础上加用加味银翘汤治疗。3组均连续治疗5 d,评价有效性和安全性。结果:治疗后,与中药组比较,西药组疾病痊愈时间明显缩短,中西医联合组疾病痊愈时间、退热时间明显缩短(P<0.05);与西药组比较,中西医联合组疾病痊愈时间、退热时间明显缩短,差异有统计学意义(P<0.05)。3组患者累积疾病痊愈率、中医证候痊愈率呈增高趋势,但差异无统计学意义(P>0.05);3组患者症状消失时间、症状消失率比较,差异无统计学意义(P>0.05);3组患者并发症发生率与不良反应发生率比较,差异无统计学意义(P>0.05)。结论:加味银翘汤治疗成人甲型流行性感冒风热夹湿证疗效与磷酸奥司他韦胶囊基本一致,联合应用可进一步缩短病程和发热病程,有快速缓解呼吸道症状的优势,安全性较好。Objective:To observe the clinical efficacy of Lonicera and Forsythia Decoction on adult influenza A(wind-heat with dampness syndrome).Methods:A single-center,prospective,cohort study design was adopted.Patients with influenza A(wind-heat with dampness syndrome) were selected as the research subjects.Two exposure factors(Modified Lonicera and Forsythia Decoction and Oseltamivir) were set,and the patients were divided into three groups:the Chinese medicinal group,the Western medicine group,and the combined traditional Chinese and Western medicine group.The Chinese medicinal group was treated with Modified Lonicera and Forsythia Decoction;the Western medicine group was treated with Oseltamivir Phosphate Capsules,and the combined traditional Chinese and Western medicine group was treated with Modified Lonicera and Forsythia Decoction in addition to the Western medicine group′s treatment.All groups were treated for 5 consecutive days,and the efficacy and safety were evaluated.Results:After treatment,compared with the Chinese medicinal group,the disease recovery time and fever subsidence time of the Western medicine group and the combined traditional Chinese and Western medicine group were significantly shortened.Compared with the Western medicine group,the disease recovery time and fever subsidence time of the combined traditional Chinese and Western medicine group were significantly shortened,with statistically significant differences(P<0.05).The cumulative disease recovery rate and the recovery rate of TCM syndromes in the three groups showed an increasing trend,but the differences were not statistically significant(P>0.05).There were no statistically significant differences in the symptom disappearance time and symptom disappearance rate among the three groups(P>0.05).There were no statistically significant differences in the incidence of complications and adverse reactions among the three groups(P>0.05).Conclusion:The efficacy of Modified Lonicera and Forsythia Decoction in the treatment of adult influenza A(win

关 键 词：甲型流行性感冒 风热夹湿证 加味银翘汤 磷酸奥司他韦胶囊 

分 类 号：R277.511.7[医药卫生—中医学]