利湿泄浊方治疗急性痛风性关节炎临床研究  

Clinical Study on the Treatment of Acute Gouty Arthritis with Dampness-Draining and Turbidity-Discharging Formula

作　　者：张良梅 郑仁东[2] 葛菁 张小改 ZHANG Liangmei;ZHENG Rendong;GE Jing;ZHANG Xiaogai(Lishui District Hospital of Traditional Chinese Medicine in Nanjing,Clinical College of the Medical School of Yangzhou University,Nanjing,Jiangsu,China,211200;Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine,Nanjing,Jiangsu,China,210028)

机构地区：[1]南京市溧水区中医院,扬州大学医学院临床学院,江苏南京211200 [2]南京中医药大学附属中西医结合医院,江苏南京210028

出　　处：《河南中医》2025年第4期601-605,共5页Henan Traditional Chinese Medicine

基　　金：国家中医药管理局西医学习中医优秀人才研修项目{国中医药人教发[2019]13号}。

摘　　要：目的:观察利湿泄浊方治疗急性痛风性关节炎的临床疗效。方法:选择2019年1月至2022年4月南京市溧水区中医院收治的80例急性痛风性关节炎患者为研究对象,按照随机数字表法分为对照组和试验组,每组各40例。对照组采用常规治疗,试验组在对照组治疗的基础上联合利湿泄浊方治疗。比较两组患者的临床疗效及不良反应发生率,检测两组患者治疗前后尿酸(uric acid,UA)、白细胞计数(white blood cell,WBC)、红细胞沉降率(erythrocyte sedimentation rate,ESR)及C反应蛋白(C reactive protein,CRP)水平。结果:对照组有效率为77.5%,试验组有效率为90.0%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后UA含量低于本组治疗前,治疗后试验组UA含量为(424.07±76.84)μmol·L^(-1),低于对照组的(464.38±69.31)μmol·L^(-1),差异具有统计学意义(P<0.05)。两组患者治疗后ESR、WBC及CRP低于本组治疗前,治疗后试验组ESR、WBC及CRP分别为(24.83±14.07)mm·h^(-1)、(9.88±1.79)×10^(9)L^(-1)、(33.24±22.45)mg·L^(-1),均低于对照组治疗后,差异具有统计学意义(P<0.05)。试验组不良反应发生率为5.0%,低于对照组的10.0%(P<0.05)。结论:利湿泄浊方治疗急性痛风性关节炎,能够改善患者临床症状,降低尿酸及炎症因子水平。Objective:To observe the clinical efficacy of Dampness-Draining and Turbidity-Discharging Formula on acute gouty arthritis.Methods:A total of 80 patients with acute gouty arthritis admitted to Lishui District Hospital of Traditional Chinese Medicine in Nanjing from January 2019 to April 2022 were selected as the research subjects and randomly divided into the control group and the experimental group,with 40 cases in each group.The control group received conventional treatment,while the experimental group was treated with Dampness-Draining and Turbidity-Discharging Formula on the basis of the control group′s treatment.The clinical efficacy and the incidence of adverse reactions were compared between the two groups.The levels of uric acid(UA),white blood cell count(WBC),erythrocyte sedimentation rate(ESR),and C-reactive protein(CRP) were detected in the two groups before and after treatment.Results:The effective rate of the control group was 77.5%,while that of the experimental group was 90.0%.The rate showed a statistically significant difference(P<0.05).After treatment,the UA level of each group was lower than that of the same group before treatment.The UA level of the experimental group after treatment was(424.07±76.84) μmmol·L^(-1),which was lower than that of the control group(464.38±69.31) μmmol·L^(-1),and the difference was statistically significant(P<0.05).The ESR,WBC and CRP of the two groups were lower than those before treatment.The ESR,WBC and CRP of the experimental group were(24.83±14.07) mm·h^(-1),(9.88±1.79)×10~9·L^(-1) and(33.24±22.45) mg·L^(-1) respectively,which were all lower than those of the control group,and all the differences were statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 5%,which was lower than that of the control group(10%)(P<0.05).Conclusion:Dampness-Draining and Turbidity-Discharging Formula can improve the clinical symptoms of patients with acute gouty arthritis,reduce their uric acid and inflammatory factor levels

关 键 词：急性痛风性关节炎 利湿泄浊方 双氯芬酸钠缓释片 泼尼松片 中西医结合疗法 

分 类 号：R274.984.3[医药卫生—中西医结合]