胺碘酮联合门冬氨酸钾镁对急诊急性心肌梗死并发恶性心律失常患者救治效果及心肌损伤指标的影响  

Effects of Amiodarone Combined with Potassium Magnesium Aspartate on the Therapeutic Effect and Myocardial Injury Indexes of Patients with Acute Myocardial Infarction Complicated with Malignant Arrhythmia

作　　者：谢华磊 王云鹏[2] 田之雷 郭旖旎 XIE Hualei;WANG Yunpeng;TIAN Zhilei;GUO Yini(Department of Emergency,Liaocheng Second Affiliated Hospital of Shandong First Medical University,Liaocheng 252000,China;Department of Cardiology,The Second People's Hospital of Liaocheng,Liaocheng 252000,China;Department of Emergency,The Second People's Hospital of Liaocheng City,Liaocheng 252000,China;Department of Hematology and Rheumatology,The Second People's Hospital of Liaocheng City,Liaocheng 252000,China)

机构地区：[1]山东第一医科大学附属聊城二院急诊,山东聊城252000 [2]山东省聊城市第二人民医院心内科一病区,山东聊城252000 [3]山东省聊城市第二人民医院急诊科,山东聊城252000 [4]山东省聊城市第二人民医院血液风湿科,山东聊城252000

出　　处：《中国伤残医学》2025年第5期31-34,45,共5页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探究胺碘酮联合门冬氨酸钾镁对急诊急性心肌梗死(AMI)并发恶性心律失常患者救治效果及心肌损伤指标的影响。方法:回顾性分析2021年10月—2023年10月山东第一医科大学附属聊城二院急诊收治的108例AMI并发恶性心律失常患者的临床资料,根据治疗方法的不同将其分为对照组和研究组,各54例。对照组采用胺碘酮治疗,研究组采用胺碘酮联合门冬氨酸钾镁治疗。两组均持续治疗4周。比较两组临床疗效、心肌损伤指标、心功能指标及不良反应发生情况。结果:研究组治疗总有效率为94.44%,高于对照组的81.48%,差异有统计学意义(P<0.05)。治疗后,研究组血清肌酸激酶同工酶、心肌肌钙蛋白I、乳酸脱氢酶、肌红蛋白水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,研究组左心射血分数高于对照组,左室舒张末期内径、左室收缩末期内径均短于对照组,差异均有统计学意义(P<0.05)。研究组的不良反应发生率为11.11%,高于对照组的7.41%,但两组比较,差异无统计学意义(P>0.05)。结论:在AMI并发恶性心律失常患者的治疗中使用胺碘酮联合门冬氨酸钾镁治疗的临床效果明显,能够有效改善其心肌损伤指标及心功能,安全性较高。Objective:To explore the effects of Amiodarone combined with Potassium Magnesium Aspartate on the therapeutic effect and myocardial injury indexes of patients with acute myocardial infarction(AMI)complicated with malignant arrhythmia.Methods:The clinical data of 108 patients with AMI complicated with malignant arrhythmia admitted to the emergency department of Liaocheng Second Hospital Affiliated to Shandong First Medical University from October 2021 to October 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and study group,with 54 cases in each group.The control group was treated with Amiodarone,and the study group was treated with Amiodarone combined with Potassium Magnesium Aspartate.Both groups were treated for 4 weeks.The clinical efficacy,myocardial injury indexes,cardiac function indexes and the occurrence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 94.44%,which was higher than 81.48%of the control group,with statistical significance(P<0.05).After treatment,the serum creatine kinase isoenzyme,cardiac troponin I,lactate dehydrogenase and muscle red egg white water in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,left ventricular ejection fraction in the study group was higher than that in the control group,and left ventricular end-diastolic diameter and left ventricular end-systolic diameter were shorter than that in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was 11.11%,which was higher than 7.41%in the control group,but there was no significant difference between the two groups(P<0.05).Conclusion:Amiodarone combined with Potassium Magnesium Aspartate has obvious clinical efficacy in the treatment of AMI patients with malignant arrhythmia,and can effectively improve myocardial injury indexes and cardiac fu

关 键 词：急性心肌梗死 恶性心律失常 胺碘酮 门冬氨酸钾镁 救治效果 心肌损伤 心功能 不良反应 

分 类 号：R65[医药卫生—外科学]