拉贝洛尔联合硝苯地平缓释片治疗妊娠期高血压的效果观察  

Observation on the Effect of Labetalol Combined with Nifedipine Sustained-Release Tablets in the Treatment of Hypertension During Pregnancy

作　　者：李凌洁 张琳琳 LI Lingjie;ZHANG Linlin(Department of Obstetrics,Liaocheng Dongchangfu Maternal and Child Health Hospital,Liaocheng 252000,China)

机构地区：[1]山东省聊城市东昌府区妇幼保健院产科,山东聊城252000

出　　处：《中国伤残医学》2025年第5期64-67,共4页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探讨拉贝洛尔联合硝苯地平缓释片治疗妊娠期高血压(HDP)的效果。方法:选取2021年9月—2023年11月聊城市东昌府区妇幼保健院收治的86例HDP患者为研究对象,按随机数字表法将其分为对照组及研究组,各43例。对照组采用拉贝洛尔治疗,研究组在此基础上采用硝苯地平缓释片治疗。两组均治疗7 d。比较两组治疗效果、血压水平、脐动脉血流动力学、血清学指标及不良反应发生情况。结果:研究组的治疗总有效率为95.35%,高于对照组的81.40%,差异有统计学意义(P<0.05)。治疗后,研究组的收缩压(SBP)、舒张压(DBP)分别为(129.57±7.45)mmHg、(85.36±6.81)mmHg,均低于对照组的(141.37±8.92)mmHg、(96.28±8.02)mmHg,差异均有统计学意义(P<0.05)。治疗后,研究组的血浆黏度、脐动脉SBP与DBP的血流峰速比、阻力指数、血细胞比容分别为(2.86±0.43)mPa·s、(1.67±0.20)、(0.29±0.08)%、(32.22±3.57)%,均低于对照组的(3.39±0.51)mPa·s、(2.01±0.37)%、(0.37±0.10)%、(37.44±4.19)%,差异均有统计学意义(P<0.05)。治疗后,研究组的C反应蛋白、同型半胱氨酸水平均分别为(10.13±1.44)μmmol/L、(6.27±1.18)mg/L,均低于对照组的(13.22±2.53)μmmol/L、(8.03±1.37)mg/L,差异均有统计学意义(P<0.05)。研究组的不良反应发生率为4.65%,低于对照组的9.30%,但两组间比较,差异无统计学意义(P>0.05)。结论:拉贝洛尔联合硝苯地平缓释片可更好地控制HDP患者的血压水平,改善其脐动脉血流动力学、血清学指标,安全有效。Objective:To investigate the effect of Labetalol combined with Nifedipine Sustained-Release Tablets in the treatment of hypertension during pregnancy(HDP).Methods:A total of 86 HDP patients admitted to Liaocheng Dongchangfu Maternal and Child Health Hospital from September 2021 to November 2023 were selected as the study objects and were divided into a control group and a study group according to random number table method,with 43 cases in each group.The control group was treated with Labetalol,and the study group was treated with Nifedipine Sustained-Release Tablets on this basis.Both groups we no tiveated 7 d.The therapeutic effect,blood pressure levels,umbilical artery hemodynamics,serological indexes and occurrence of adverse reactions of the two groups were compared.Results:The total effective rate of the study group was 95.35%,which was higher than 81.40%of the control group,the difference was statistically significant(P<0.05).After treatment,the systolic blood pressure(SBP)and diastolic blood pressure(DBP)of the study group were(129.57±7.45)mmHg and(85.36±6.81)mmHg,respectively,which were lower than(141.37±8.92)mmHg and(96.28±8.02)mmHg of the control group,the differences were statistically significant(P<0.05).After treatment,the plasma viscosity,peak velocity ratio of umbilical artery SBP to DBP,resistance index and hematocrit in the study group were(2.86±0.43)mPa·s,(1.67±0.20)%,(0.29±0.08)%and(32.22±3.57)%,respectively,which were lower than(3.39±0.51)mPa·s,(2.01±0.37)%,(0.37±0.10)%and(37.44±4.19)%in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of C-reactive protein and homocysteine in the study group were(10.13±1.44)μmmol/L and(6.27±1.18)mg/L,respectively,which were lower than(13.22±2.53)μmmol/L and(8.03±1.37)mg/L in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was 4.65%,which was lower than 9.30%in the control group,but there was no statistical

关 键 词：妊娠期高血压 拉贝洛尔 硝苯地平缓释片 治疗效果 血压 脐动脉血流动力学 

分 类 号：R714[医药卫生—妇产科学]