单针射频联合白灵片对稳定期非节段型白癜风经络瘀阻证的治疗效果  

Therapeutic effect of single needle radiofrequency combined with Bailing tablets on syndrome of meridian obstruction in stable non-segmental vitiligo

作　　者：徐婉妮 杨广智[1] 刘靖[2] XU Wanni;YANG Guangzhi;LIU Jing(Department of Dermatology,Xiaolan People's Hospital of ZhongShan&Fifth People's Hospital of Zhongshan,Zhongshan 528415,Guangdong,China;Department of Dermatology,First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,Guangdong,China)

机构地区：[1]中山市小榄人民医院&中山市第五人民医院皮肤科,广东中山528415 [2]广州中医药大学第一附属医院皮肤科,广东广州510405

出　　处：《贵州医科大学学报》2025年第3期434-441,449,共9页Journal of Guizhou Medical University

基　　金：广东省中医药局科研项目(20192109)。

摘　　要：目的探讨单针射频联合白灵片治疗稳定期非节段型白癜风经络瘀阻证的疗效及安全性。方法将66例稳定期非节段型白癜风患者随均机分为3组,治疗组运用单针射频联合白灵片治疗,对照1组予窄谱中波紫外线(narrow bound ultra violet B light,NB-UVB)联合白灵片治疗,对照2组予白灵片治疗,疗程12周;比较3组患者的一般资料、治疗后疗效,观察治疗前及治疗第4、8及12周时白斑面积、色素恢复情况(平均复色率、白斑色素积分),记录治疗期间不良反应情况;随访12周,观察预后。结果3组患者性别、年龄、病程、白斑数量及面积、白斑部位比较,差异无统计学差异(P>0.05),具有可比性;治疗组显效率明显高于对照1组和对照2组(P<0.001);治疗后,治疗组白斑面积小于对照1组及对照2组(P<0.05);治疗第4周开始,治疗组白癜风患者白斑处的复色率明显高于对照1组和对照2组(P<0.001);治疗前,治疗组与对照1组和对照2组白斑色素积分比较,差异无统计学意义(P>0.05);治疗12周,治疗组白斑色素积分明显高于与对照1组和对照2组(P<0.001);在治疗期间,所有患者均未出现严重不良反应,3组不良反应发生率比较,差异无统计学意义(P>0.05);治疗结束后随访患者12周,患者无明显新发白斑及迟发不良反应。结论单针射频联合白灵片治疗稳定期非节段型白癜风经络瘀阻证临床疗效好,不良反应少。Objective To investigate the efficacy and safety of single needle radiofrequency combined with Bailing tablets in treating non-segmental vitiligo with meridian obstruction in stable phase.Method Sixty-six patients with stable non-segmental vitiligo were randomly divided into 3 groups.The treatment group was treated with single needle radiofrequency combined with Bailin tablets.The first group was treated with narrow spectrum medium wave ultraviolet light(narrow bound ultra violet B light,NB-UVB)combined with Bailing tablets,and the second group was treated with Bailing tablets for 12 weeks.The general data and therapeutic effect of the three groups were compared,and the area of white spots and pigment recovery(average color recovery rate and white spot pigment score)before treatment and at the 4th,8th and 12th weeks after treatment were observed.The adverse reactions during treatment were recorded,which was followed up for 12 weeks and the prognosis was observed.Results There was no statistical difference in gender,age,disease course,number and area of white spots and location of white spots among the three groups(P>0.05),which were comparable.The efficacy of the treatment group was significantly higher than that of the control 1 group and the control 2 group(P<0.001).There was no significant difference in the area of white spots before treatment among the three groups(P>0.05).After treatment,the area of white spots in the treatment group was smaller than that in the control 1 group and the control 2 group(P<0.05).From the fourth week of treatment,the recovery rate of white spots in vitiligo patients in the treatment group was significantly higher than that in the control 1 group and the control 2 group(P<0.001).Before treatment,there was no significant difference between the treatment group and the control 1 group and the control 2 group in terms of leukoplakia pigment score(P>0.05).After 12 weeks of treatment,the pigment score of white spots in the treatment group was higher than that in the control group 1 and

关 键 词：白癜风 单针射频 白灵片 窄谱中波紫外线 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]