丙泊酚联合依托咪酯在经皮椎体成形术中对OVCF患者麻醉效果的影响及安全性分析  

Analysis the Anesthesia Effect and Safety of Propofol Combined with Etomidate in Percutaneous Vertebroplasty of Patients with OVCF

作　　者：周栋清 ZHOU Dongqing(Department of Anesthesiology,Gaomi Second People’s Hospital,Weifang 261000,China)

机构地区：[1]山东省高密市第二人民医院麻醉科,山东潍坊261000

出　　处：《中国伤残医学》2025年第6期68-71,76,共5页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:评估丙泊酚联合依托咪酯在经皮椎体成形术(PVP)中对骨质疏松性椎体压缩性骨折(OVCF)患者麻醉效果的影响及其安全性。方法:选取2020年3月-2024年9月于高密市第二人民医院接受PVP治疗的107例OVCF患者为研究对象,根据随机数字表法将其分为对照组(n=54)和研究组(n=53)。对照组采用依托咪酯进行麻醉,研究组采用丙泊酚联合依托咪酯进行麻醉。比较两组生命体征、不良反应发生情况及认知功能障碍发生情况。结果:麻醉诱导后5 min、手术开始时及手术结束时,研究组的心率、平均动脉压均低于对照组,血氧饱和度均高于对照组,差异均有统计学意义(P<0.05)。研究组围手术期不良反应发生率为16.98%,高于对照组的11.11%,但两组比较,差异无统计学意义(P>0.05)。研究组术后认知功能障碍发生率为0.00%,低于对照组的11.11%,差异有统计学意义(P<0.05)。结论:丙泊酚联合依托咪酯在PVP中能够为OVCF患者提供更平稳的麻醉效果,并且围手术期不良反应发生率和术后认知功能障碍发生率较低,是安全有效的麻醉方案。Objective:To evaluate of the anesthesia effect and safety of Propofol combined with Etomidate in percutaneous vertebroplasty(PVP)of patients with osteoporotic vertebral compression fracture(OVCF).Methods:A total of 107 OVCF patients treated with PVP admitted to Gaomi Second People’s Hospital from March 2020 to September 2024 were selected as the study objects,and were divided into a control group(n=54)and a study group(n=53)according to the random number table method.The control group was anesthetized with Etomidate alone,while the study group was anesthetized with Propofol compounded with Etomidate.The vital signs,the adverse reactions and the cognitive dysfunction occurrence were compared between the two groups.Results:At 5 min after the induction of anesthesia,the beginning of the operation and the end of the operation,the heart rate and mean arterial pressure of the study group were lower than those of the control group,and the blood oxygen saturation were higher than that of the control group,with statistical significance(P<0.05).The incidence of perioperative adverse reactions in the study group was 16.98%,which was higher than 11.11%in the control group,but there was no significant difference between the two groups(P>0.05).The incidence of postoperative cognitive dysfunction in the study group was 0.00%,which was lower than 11.11%in the control group,with statistical significance(P<0.05).Conclusion:Propofol combined with Etomidate can provide smoother anesthesia effect in percutaneous vertebroplasty of patients with OVCF,and the incidence of perioperative adverse reactions and postoperative cognitive dysfunction is relatively low,which is a safe and effective anesthesia regimen.

关 键 词：骨质疏松性椎体压缩性骨折 经皮椎体成形术 丙泊酚 依托咪酯 麻醉效果 安全性 

分 类 号：R68[医药卫生—骨科学]