PD-1/PD-L1信号通路在病原感染中作用的研究进展  

Progress on the Role of PD-1/PD-L1 Passway in Pathogenic Infections

作　　者：孙艳秋 王勃森 李宁[1] 郭抗抗[1] SUN Yan-qiu;WANG Bo-sen;LI Ning;GUO Kang-kang(College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi 712100,China;Meixian Animal Husbandry and Veterinary Technology Promotion Station,Meixian,Shaanxi 722300,China)

机构地区：[1]西北农林科技大学动物医学院,陕西杨陵712100 [2]眉县畜牧兽医技术推广站,陕西眉县722300

出　　处：《动物医学进展》2025年第4期107-113,共7页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(32272997)。

摘　　要：免疫系统是机体维持正常生理功能的重要系统,多种免疫细胞表面的程序性死亡受体-1(programmed cell death protein 1,PD-1)及其配体程序性死亡配体-1(programmed cell death-ligand 1,PD-L1)是重要的共抑制分子,在病理状态下能够传递免疫抑制信号,导致T细胞失能,从而引发免疫系统的功能障碍。研究表明,PD-1/PD-L1通路通过调控相关细胞因子及多种下游信号等方式,在多种疾病发生发展过程中发挥重要作用。论文对PD-1/PD-L1的结构、表达调控、作用机制及其在微生物、寄生虫等病原感染中作用的研究进展进行总结分析,以期为深入研究和揭示PD-1/PD-L1在疾病发生,特别是在病原微生物感染中的作用及相关疾病的防治提供基础资料。The immune system is an important system for the body to maintain normal physiological functions,and the programmed cell death protein 1(PD-1)and its ligand programmed cell death-ligand 1(PD-L1)on the surface of various immune cells are important co-inhibitory molecules.Under pathological conditions,they can transmit immunosuppressive signals,leading to the dysfunction of T cell and immune system.Research shows that the PD-1/PD-L1 pathway plays an important role in the development of various diseases by regulating related cytokines and various downstream signals.This article summarizes and analyzes the structure,expression regulation,mechanism of action of PD-1/PD-L1,and its role in microbial and parasitic infections,aiming to provide basic information for further research and revealing the role of PD-1/PD-L1 in the occurrence of diseases,especially in the infections of pathogenic microorganisms.

关 键 词：T细胞 程序性死亡受体-1 程序性死亡配体-1 病原感染 

分 类 号：S852.4[农业科学—基础兽医学] S852.3[农业科学—兽医学]