冷冻复融放散法与改良56℃热放散法对新生儿ABO溶血病的诊断效能比较  

Comparison of the diagnostic efficacy of the freeze-thaw elution method and the modified 56°C heat elution method for neonatal ABO hemolytic disease

作　　者：许秀兰 李永芳 燕备战 Xu Xiulan;Li Yongfang;Yan Beizhan(Department of Blood Transfusion,Henan Provincial People's Hospital(People's Hospital of Zhengzhou University),Zhengzhou,Henan 450003,China;Department of Blood Transfusion,Hongxing Hospital of the 13th Division of Xinjiang Production and Construction Corps,Hami,Xinjiang Uygur Autonomous Region 839000,China)

机构地区：[1]河南省人民医院(郑州大学人民医院)输血科,河南郑州450003 [2]新疆生产建设兵团第十三师红星医院输血科,新疆维吾尔自治区哈密839000

出　　处：《现代临床医学》2025年第2期92-95,共4页Journal of Modern Clinical Medicine

摘　　要：目的:探讨冷冻复融放散法与改良56℃热放散法对新生儿ABO溶血病的诊断效能。方法:选择河南省人民医院2023年1月至2024年1月收治的106例新生儿溶血病患儿为研究对象,以抗人球蛋白试验为金标准,比较冷冻复融放散法、改良56℃热放散法对新生儿ABO溶血病的诊断效能。结果:冷冻复融放散法与金标准一致性较差(Kappa=0.383),改良56℃热放散法与金标准一致性较好(Kappa=0.703)。改良56℃热放散法的诊断准确率、敏感度、特异度、阳性预测值、阴性预测值高于冷冻复融放散法(P<0.05)。改良56℃热放散法检查诊断的ROC曲线下面积为0.821,高于冷冻复融放散法的0.714。结论:改良56℃热放散法对新生儿ABO溶血病具有较高的诊断价值,其检测敏感度、特异度、准确度更高。Objective:To explore the diagnostic efficacy of the freeze-thaw elution method and the modified 56 C heat elution method for neonatal ABO hemolytic disease.Methods:A total of 106 neonates with hemolytic disease admitted to Henan Provincial People's Hospital from January 2023 to January 2024 were selected as the research subjects.With the Coombs test as the gold standard,the diagnostic efficacy of the freeze-thaw elution method and the modified 56℃heat elution method for neonatal ABO hemolytic disease was compared.Results:The consistency between the freeze-thaw elution method and the gold standard was poor(Kappa=0.383),while the consistency between the modified 56℃ heat elution method and the gold standard was good(Kappa=0.703).The diagnostic accuracy,sensitivity,specificity,positive predictive value,and negative predictive value of the modified 56℃ heat elution method were higher than those of the freeze-thaw elution method(P<0.05).The area under the ROC curve of the diagnosis by the modified 56℃ heat elution method was 0.821,which was higher than 0.714 of the freeze-thaw elution method.Conclusion:The modified 56℃heat elution method has a high diagnostic value for neonatal ABO hemolytic disease,with higher detection sensitivity,specificity,and accuracy.

关 键 词：冷冻复融放散法 改良56℃热放散法 ABO型 新生儿溶血病 诊断效能 

分 类 号：R722.18[医药卫生—儿科]