血管细胞粘附分子1与缺血性和非缺血性心衰发生全因死亡的相关性  

Correlation of vascular cell adhesion molecule-1 with all-cause mortality in ischemic and non-ischemic heart failure

作　　者：郭爽 李树仁[1] 郝潇[1] GUO Shuang;LI Shu-ren;HAO Xiao(Department of Cardiology,Hebei Provincial People’s Hospital,Shijiazhuang 050057,Hebei,China)

机构地区：[1]河北省人民医院心内科,河北石家庄050057

出　　处：《心脏杂志》2025年第2期152-156,177,共6页Chinese Heart Journal

摘　　要：目的探究血管细胞粘附分子1(VCAM-1)与IHF和非IHF患者临床预后的相关性。方法纳入2019年3月~2020年3月于河北省人民医院心内科住院的慢性心力衰竭(HF)患者208例,根据病因不同分为IHF组(n=92)和非IHF组(n=116)。比较2组患者的临床资料及VCAM-1的浓度水平,并将2组患者依据3年内是否发生全因死亡进行亚组分析,采用COX回归分析不同组别中影响预后的相关因素。结果①VCAM-1水平在IHF组与非IHF组差异无统计学意义,IHF患者发生全因死亡组VCAM-1水平高于未发生全因死亡组(P<0.01),而非IHF患者的VCAM-1水平在是否发生全因死亡两组之间无明显差异;②多因素COX回归分析显示,VCAM-1(HR=1.005,95%CI:1.001~1.009,P<0.05)和左室射血分数(HR=0.908,95%CI:0.830~0.993,P<0.05)为IHF患者发生全因死亡的影响因素;③多因素COX回归分析结果显示,VCAM-1不是非IHF患者全因死亡发生全因死亡的影响因素(HR=0.998,95%CI:0.995~1.001,P=0.998)。结论VCAM-1与IHF的预后明显相关,高水平VCAM-1是IHF患者发生全因死亡的危险因素。AIM To investigate the correlation between vascular cell adhesion molecule 1(VCAM-1)and the prognosis of patients with ischemic heart failure(IHF)and non-IHF.METHODS A total of 208 patients with chronic HF who were hospitalized in the Cardiovascular Department of Hebei Provincial People’s Hospital from March 2019 to March 2020 were selected and they were divided into the IHF group(n=92)and the non-IHF group(n=116)according to the etiology.The clinical data and the concentration level of VCAM-1 were compared between the two groups.The patients were sub-grouped according to the occurrence of all-cause death within 3 years and COX regression was used to analyze the prognosis in the different groups.RESULTS①There was no statistically significant difference in VCAM-1 levels between the IHF group and the non IHF group.The VCAM-1 levels in the group with all cause mortality in IHF patients were higher than those in the group without all cause mortality(P<0.01),while there was no significant difference in VCAM-1 levels between the two groups with and without all cause mortality in non IHF patients;②Multivariate COX regression analysis showed that VCAM-1(HR=1.005,95%CI:1.001~1.009,P<0.05)and left ventricular ejection fraction(HR=0.908,95%CI:0.830~0.993,P<0.05)were the influencing factors for all-cause mortality in IHF patients;③Multivariate COX regression analysis showed that VCAM-1 was not a factor for all-cause mortality in non IHF patients(HR=0.998,95%CI:0.995~1001,P=0.998).CONCLUSION VCAM-1 is significantly associated with the prognosis of IHF patients and high levels of VCAM-1 increase the risk of all-cause mortality in patients with IHF.

关 键 词：缺血性心力衰竭 心力衰竭 血管细胞粘附分子1 COX回归 

分 类 号：R541.6[医药卫生—心血管疾病]