肌因子在心血管疾病中作用及其机制的研究进展  

Research progress on the roles and mechanisms of myokines in cardiovascular diseases

作　　者：王孙云澍 薛慧敏 李泽 李凯峰 邢文娟 韩继明[1] 张海锋 WANGSUN Yun-shu;XUE Hui-min;LI Ze;LI Kai-feng;XING Wen-juan;HAN Ji-ming;ZHANG Haifeng(School of Medicine,Yan’an University,Yan’an 716000,Shaanxi,China;Experimental Teaching Center of Basic Medical Sciences,School of Aerospace and Aviation Medicine,Air Force Medical University,Xi’an 710032,Shaanxi,China;Department of Recuperation and Rehabilitation for Flight Personnel,School of Aerospace and Aviation Medicine,Air Force Medical University,Xi’an 710032,Shaanxi,China)

机构地区：[1]延安大学医学院,陕西延安716000 [2]空军军医大学基础医学院基础医学教学实验中心,陕西西安710032 [3]空军军医大学航空航天医学系飞行人员疗养与康复教研室,陕西西安710032

出　　处：《心脏杂志》2025年第2期188-192,197,共6页Chinese Heart Journal

基　　金：国家自然科学基金项目(32371239,32071107);陕西省青年科技新星项目(2021KJXX-21);陕西省重点研发计划项目(2024SF-YBXM-018)。

摘　　要：肌因子(myokines)作为骨骼肌分泌的活性物质,在诸多生理过程中发挥重要作用。肌因子作为运动因子,易由于机体运动而发生改变,分泌并介导心血管稳态及全身代谢,如改善心肌细胞和内皮细胞功能、葡萄糖稳态、胰岛素抵抗、脂质代谢等,并进一步缓解心血管损伤,但机制尚有待深入研究。本文就肌因子对心血管系统的生理学和病理生理学作用的研究进展做一综述。As an active substance secreted by skeletal muscle,muscle factors(myokines)play an important role in many physiological processes.During exercise,skeletal muscles contract and send out signals to promote the secretion of myokines,which mediate the interactions between muscle and heart and vascular bed through endocrine entry into circulation.As an exercise factor,myokines are easy to be changed by body exercise,secrete and mediate cardiovascular homeostasis and systemic metabolism,such as improving endothelial cell function,cardiomyocyte apoptosis,glucose homeostasis,insulin resistance and lipid metabolism,and further alleviate cardiovascular injury,but the mechanisms remain largely unclear.In this article,we reviewed the research progress of the pathophysiological effects of myokines on the cardiovascular system.

关 键 词：肌因子 心血管疾病 运动 

分 类 号：R54[医药卫生—心血管疾病]