SIRT1/AMPK信号通路与动脉粥样硬化的研究进展  

Research progress on the correlation between SIRT1/AMPK signaling pathway and atherosclerosis

作　　者：李秋雨 王帅[1] LI Qiu-yu;WANG Shuai(Three Departments of Cardiology,Affiliated Hospital,Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学附属医院心内三科,辽宁沈阳110032

出　　处：《心脏杂志》2025年第2期193-197,共5页Chinese Heart Journal

基　　金：辽宁省自然基金项目(2023-MS-230);沈阳市科技计划项目(21-174-9-15)。

摘　　要：近年来由于动脉粥样硬化(atherosclerosis,AS)造成的死亡率急速增高,严重损害了人们的健康。本文将从氧化应激、细胞自噬、细胞凋亡以及与SIRT1/AMPK信号通路之间的关联性在AS的预防方面展开论述,并浅谈白藜芦醇、姜黄素及人参皂苷调控SIRT1/AMPK通路在AS中的作用,为疾病的发展与预防提供新的治疗思路。In recent years the mortality rate caused by Atherosclerosis(AS)has increased rapidly,which has seriously impaired people’s health.In this paper,oxidative stress,autophagy,apoptosis and the relationship between SIRT1/AMPK signaling pathway are discussed in the prevention of atherosclerosis,and the role of resveratrol,curcumin and ginsenoside in regulating SIRT1/AMPK pathway in AS is discussed,providing new therapeutic ideas for the development and prevention of the disease.

关 键 词：氧化应激 细胞自噬 细胞凋亡 SIRT1/AMPK 动脉粥样硬化 

分 类 号：R285.5[医药卫生—中药学]