RhoA-ROCK信号通路参与肺动脉高压发病机制研究进展  

Research progress in participation of RhoA-ROCK signaling pathway in pathogenesis of pulmonary hypertension

作　　者：杨倩倩 王忠超 YANG Qian-qian;WANG Zhong-chao(Department of Congenital Heart Disease,General Hospital of Northern Theater Command&Military Institute of Cardiovascular Disease,Shenyang 110016,Liaoning,China;Graduate School,Dalian Medical University,Dalian 116044,Liaoning,China)

机构地区：[1]中国人民解放军北部战区总医院先心病内科、全军心血管病研究所,辽宁沈阳110016 [2]大连医科大学研究生院,辽宁大连116044

出　　处：《心脏杂志》2025年第2期204-209,215,共7页Chinese Heart Journal

基　　金：辽宁省兴辽英才计划项目(XLYC2007020)。

摘　　要：肺动脉高压(pulmonary hypertension,PH)是一种主要累及肺血管床的慢性进行性病变,其病理基础主要为内皮功能障碍、广泛的肺动脉异常收缩及肺血管重塑,最终可致右心衰竭甚至死亡。近年研究表明,RhoA-ROCK通路在调节血管平滑肌细胞收缩、增殖、迁移等细胞功能中发挥重要作用,同时深入参与血管张力调节、内皮功能障碍、氧化应激、炎性反应等重要病理生理学进程,上述作用均与PH的发病机制密切相关。因此,本文主要探讨RhoA-ROCK信号通路在PH发生发展中的作用,以及与该通路有关的PH靶向干预的最新进展。Pulmonary hypertension(PH)is a progressively chronic disease mainly affecting the pulmonary vascular bed.The main pathological basis is endothelial dysfunction,extensive pulmonary artery constrictive abnormality and pulmonary vascular remodeling,which can eventually lead to right heart failure and even death.Recent studies have shown that the RhoA-ROCK pathway plays an important role in regulating cellular functions,including vascular smooth muscle cell contraction,proliferation and migration.It is also deeply involved in important pathophysiological processes such as vascular tone regulation,endothelial cell dysfunction,oxidative stress and inflammatory responses.All the above points are closely related to the pathogenesis of PH.Therefore,this paper mainly discusses the detailed mechanisms of the RhoA-ROCK pathway involved in the development of PH,as well as recent advances in PH-targeted interventions related to this pathway.

关 键 词：肺动脉高压 RhoA-ROCK通路 肺动脉血管平滑肌细胞 内皮细胞 血管重塑 凋亡 炎性反应 

分 类 号：R544.1[医药卫生—心血管疾病]