放射性心脏损伤防治药物研究进展  

Research progress in drugs for prevention and treatment of radiation induced heart injury

作　　者：张雅 徐闵 王海波 ZHANG Ya;XU MIN;WANG Hai-bo(Department of Chinese Materia Medica and Natural Medicines,School of Pharmacy,Air Force Medical University,Xi’an 710032,Shaanxi,China;Department of Chemistry,School of Pharmacy,Air Force Medical University,Xi’an 710032,Shaanxi,China;Third Outpatient Department,General Hospital,Central Theater Command,Wuhan 430070,Hubei,China)

机构地区：[1]空军军医大学药学系中药与天然药物学教研室,湖北武汉430070 [2]空军军医大学药学系化学制药学教研室,陕西西安710032 [3]中部战区总医院第三派驻门诊部,湖北武汉430070

出　　处：《心脏杂志》2025年第2期228-235,共8页Chinese Heart Journal

基　　金：国家自然科学基金面上项目(81973236);国家自然科学基金青年项目(82204586);陕西省重点研发计划项目(2023-YBSF-311)。

摘　　要：近年来,随着肿瘤治疗技术的不断提高,患者的生存期延长,放射治疗所引起的放射性心脏损伤问题日益凸显,降低在放疗过程中出现的心脏并发症已成为研究的重要方向。本文综述了近年来对放射性心脏病(RIHD)发生机制的研究进展,总结了RIHD的一些常见临床症状,重点阐述了抗辐射损伤药物、心脏保护类药物对RIHD的防治研究情况,以期为研究药物对RIHD进行预防和治疗的策略提供文献支撑。In recent years,with the continuous improvement of tumor treatment technology,the survival time of patients has been extended and the problem of radiation induced cardiac injury has become increasingly prominent.Reducing the cardiac complications that occur during radiotherapy has become an important research direction.This article reviews the research progress on the pathogenesis of radiation induced heart disease(RIHD)in recent years,summarizes some common clinical symptoms of RIHD and focuses on the research on the prevention and treatment of RIHD with radiation damage drugs and cardiac protective drugs,in order to provide literature support for the study of strategies for using drugs to prevent and treat RIHD.

关 键 词：放射性心脏病 肿瘤 放射疗法 防治药物 临床治疗 

分 类 号：R541.4[医药卫生—心血管疾病]