金纳米材料的合成方法及其在生物医学领域应用研究进展  

Research Progress on Synthesis Methods of Gold Nanomaterials and its Applications in Biomedical Fields

作　　者：郑祚静 林玉红 赵凯 Zheng Zuojing;Lin Yuhong;Zhao Kai(College of Life Sciences and Medicine,Zhejiang Sci-Tech University,Hangzhou 310018,China;Taizhou Key Laboratory of Biomedicine and Advanced Dosage Forms,Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation,College of Life Sciences,Taizhou University,Taizhou 318000,Zhejiang,China)

机构地区：[1]浙江理工大学生命科学与医药学院,杭州310018 [2]台州学院生命科学学院,浙江省植物进化生态学与保护重点实验室,台州市生物医药与高端剂型重点实验室,浙江台州318000

出　　处：《中国生物医学工程学报》2024年第6期730-740,共11页Chinese Journal of Biomedical Engineering

基　　金：浙江省自然科学基金联合项目(LTY22E030002);台州市科技计划项目(23gya01).

摘　　要：纳米技术逐渐成为科学前沿热点,尤其在生物医疗领域,各种金属纳米材料得到了广泛应用。其中,金纳米材料因其良好的生物相容性、独特的光学特性和易于功能化修饰等特点而备受关注。然而,传统的化学、物理以及微生物方法制备金纳米材料存在生态风险、成本高昂和操作复杂的缺陷,阻碍其促进医学应用的快速发展。鉴于绿色合成和生物合成的兴起,植物介导的金纳米材料的合成以其无污染且无毒的特点脱颖而出,显著降低了有害化学物质和有毒副产物的产出。概述了金纳米材料的不同制备方法,阐述其在药物递送、抗肿瘤治疗、抗菌、生物传感和成像等生物医学领域的应用,为更多功能化金纳米材料的开发研究提供有益借鉴。Nanotechnology has become a trend in scientific fields,and various metal nanomaterials have been widely developed in various biomedical aspects.Among them,gold nanomaterials have received special attentions due to their good biocompatibility,unique optical properties and easy to be functionalized.Nevertheless,preparations of gold nanomaterials by chemical,physical and microbial approaches suffer from environmental,economic and operational drawbacks,which limit the wide applications in industry and medicine.With the development of green synthesis and biomass synthesis,plant-mediated biosynthesis of metal nanomaterials has the advantages of non-pollution and non-toxicity,which can minimize the amount of hazardous chemicals and toxic by-products.This article reviewed the research progress of different preparation methods of gold nanomaterials and their applications in the fields of drug delivery,tumor therapy,antimicrobial,biosensing and imaging,providing references for the development research of more versatile gold nanomaterials.

关 键 词：金纳米材料 制备方法 生物应用 生物安全性 

分 类 号：R318[医药卫生—生物医学工程]