重组胶原蛋白在组织再生中的应用  

Application of Recombinant Collagen in Tissue Regeneration

作　　者：张悦[1,2] 贾元元 孙秀丽 王建六[1,2] Zhang Yue;Jia Yuanyuan;Sun Xiuli;Wang Jianliu(Department of Obstetrics and Gynecology,Peking University People′s Hospital,Beijing 100044,China;Beijing Key Laboratory of Female Pelvic Floor Disorders,Beijing 100044,China)

机构地区：[1]北京大学人民医院妇产科,北京100044 [2]女性盆底疾病研究北京市重点实验室,北京100044

出　　处：《中国生物医学工程学报》2024年第6期741-750,共10页Chinese Journal of Biomedical Engineering

基　　金：国家重点研发计划(2023YFC2411204、2023YFC2411202);国家自然科学基金(82171615)。

摘　　要：重组胶原蛋白是一类基于人特定型别胶原蛋白的功能区基因编码,利用结构生物学和基因工程等技术制备的新型生物材料。其氨基酸序列与人胶原蛋白相同或高度相似,具有低免疫原性、良好的生物相容性和生物活性,在组织损伤修复和再生医学领域展现出巨大的潜力。总结了重组胶原蛋白的分类、合成过程和作用效应,综述了其在皮肤、心血管、骨骼、角膜以及女性盆底组织再生中的研究进展,进一步讨论了当前研究的局限和未来的发展方向,旨在为重组胶原蛋白的研究与应用提供新的思路。Recombinant collagen is a novel biomaterial based on the genetic coding of specific functional domains of human collagen,synthesized through structural biology,genetic engineering,and related technologies.Its amino acid sequence is either identical or highly similar to that of human collagen,endowing it with low immunogenicity,excellent biocompatibility,and significant bioactivity.Consequently,recombinant collagen has shown considerable potential in tissue repair and regenerative medicine.This paper summarized the classifications,synthesis processes,and effects of recombinant collagen,while reviewing its advancements in the application of tissue regeneration for skin,cardiovascular tissues,skeletal structures,corneas,and pelvic floor tissues.Additionally,limitations of current research and future directions were discussed,aiming to provide new insights for the research and application of recombinant collagen.

关 键 词：重组胶原蛋白 组织再生 生物活性材料 

分 类 号：R318[医药卫生—生物医学工程]