Modified logistic nanodosimetry model for calculating relative biological effectiveness  

作　　者：Jing-Fen Yang Xin-Guo Liu Hui Zhang Peng-Bo He Yuan-Yuan Ma Guo-Sheng Shen Wei-Qiang Chen Qiang Li 

机构地区：[1]Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730000,China [2]Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Science,Lanzhou 730000,China [3]Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine,Lanzhou 730000,China [4]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Nuclear Science and Techniques》2025年第4期72-81,共10页核技术(英文)

基　　金：supported by the National Key Research and Development Program of China(No.2022YFC2401503);Key Research and Development Program of Gansu Province(No.23YFFA0010);Natural Science Foundation of Gansu Province(No.23JRRA625);Special Project of Science and Technology Cooperation between Hubei Province and Chinese Academy of Sciences(No.42000021817T300000050)。

摘　　要：DNA double-strand breaks(DSBs)may result in cellular mutations,apoptosis,and cell death,making them critical determinants of cellular survival and functionality,as well as major mechanisms underlying cell death.The success of nanodosimetry lies in the reduction in the number of modeling parameters to be adjusted for the model to predict experimental data on radiation biology.Based on this background,this study modified and simplified the logistic nanodosimetry model(LNDM)based on radiation-induced DSB probability.The probability distribution of ionization cluster size P(v|Q)under irradiation with carbon-ion beams was obtained through a track-structure Monte Carlo(MC)simulation,and then,the nanodosimetric quantities and DSB probability were calculated.Combining the assumptions of the linear quadratic(LQ)model and LNDM,DSB probability-based modification and simplification of the LNDM were conducted.Additionally,based on the radiobiological experimental data of human salivary gland(HSG),Chinese hamster lung(V79),and Chinese hamster ovary(CHO-K1)cells,the least-squares method was used to optimize the parameters of the modified LNDM(mLNDM).The mLNDM accurately reproduced the experimental data of HSG,V79,and CHO-K1 cells,and the results showed that the model parameters r and m_(0) were independent of the cell type,that is,the biological effects of cells with different radiosensitivities can be characterized by adjusting only the model parameters k and P_(s→l).Compared with HSG and CHO-K1 cells,V79 cells had smaller k and P_(s→l)values,indicating that that DSBs have a lower probability of eventually causing lethal damage,and sublethal events are less likely to interact to form lethal events,thereby having radioresistant characteristics.Compared with the LNDM,the mLNDM eliminates the tedious derivation process and connects the quantities characterizing radiation quality at the nanoscale level using radiation biological effects in a more direct and easy-to-understand manner,thus providing a simpler and more accurate m

关 键 词：NANODOSIMETRY DNA double-strand break probability Biophysical model Carbon-ion radiotherapy 

分 类 号：R71[医药卫生—妇产科学]