孕早期血清维生素A、E水平与子痫前期的关联研究  

Association of serum vitamin A and vitamin E concentrations in first trimester and preeclampsia

作　　者：马尚 夏玉雯 石慧峰 魏瑗[2] 王晓莉[1] MA Shang;XIA Yuwen;SHI Huifeng;WEI Yuan;WANG Xiaoli(Department of Maternal and Child Health,School of Public Health,Peking University,Beijing 100191,China)

机构地区：[1]北京大学公共卫生学院妇幼卫生学系,100191 [2]北京大学第三医院妇产科

出　　处：《中国生育健康杂志》2025年第2期109-114,共6页Chinese Journal of Reproductive Health

基　　金：国家重点研发计划(2023YFC2705900)。

摘　　要：目的了解孕妇孕早期血清维生素A、E水平与子痫前期的关联。方法基于国家卫生健康委医药卫生科技发展研究中心开展的“孕期血清维生素A、E与子痫前期相关性研究”队列进行研究,调查内容包括孕妇基本特征、不同孕期血清维生素A、E水平、是否诊断子痫前期等。参考既往标准,将血清维生素A、E水平划分为缺乏、正常范围、过量三组,计算不同组的子痫前期患病率。应用Logistic回归模型分析孕早期维生素A、E水平与子痫前期发生风险之间的关联。结果本研究共纳入61555例孕妇,其中子痫前期患病例数为1426例,患病率为2.3%。在孕早期,子痫前期孕妇的维生素A水平与非子痫前期孕妇差异未见统计学意义,子痫前期孕妇的维生素E水平低于非子痫前期孕妇,差异具有统计学意义。孕早期维生素A缺乏组孕妇子痫前期的风险降低(OR=0.80,95%CI:0.64~0.99),孕早期维生素E缺乏组孕妇子痫前期的风险显著增加(OR=6.54,95%CI:4.98~8.59)。与孕早期维生素A、E均在正常范围的孕妇相比,孕早期维生素A在正常范围、维生素E缺乏的孕妇患子痫前期的风险显著增加(OR=11.61,95%CI:8.65~15.58)。结论孕妇血清维生素A、E水平与子痫前期有关,孕早期维生素E缺乏是子痫前期的危险因素。在孕早期监测维生素A、E水平有助于发现子痫前期高风险人群。Objective To explore the association between serum vitamin A and vitamin E concentrations in first trimester of pregnancy and preeclampsia.Methods The study was based on the cohort about the association between serum vitamins A and E during pregnancy and preeclampsia,which was conducted by Development Center for Medical Science&Technology,National Health Commission of the People′s Republic of China.It included the basic characteristics of pregnant women,serum vitamin A and E concentrations at different stages of pregnancy,and status of preeclampsia.The serum vitamin A and vitamin E concentrations were divided into three groups of deficiency,normal range,and excess.We calculated the prevalence of preeclampsia in different groups.Logistic regression models were used to analyze the association between vitamin A and vitamin E concentrations in first trimester and the risk of preeclampsia.Results A total of 61555 pregnant women were included in this study,and 1426(2.3%)were diagnosed with preeclampsia.In first trimester of pregnancy,no significant difference was found in vitamin A levels between pregnant women with preeclampsia and healthy pregnant controls.Pregnant women with preeclampsia had significantly lower levels of vitamin E in first trimester.The risk of preeclampsia was reduced in pregnant women with vitamin A deficiency(OR=0.80,95%CI:0.64-0.99),while the risk of preeclampsia was significantly increased in pregnant women with vitamin E deficiency(OR=6.54,95%CI:4.98-8.59).Pregnant women with vitamin A in the normal range and vitamin E deficiency in the first trimester had a significantly increased risk of preeclampsia compared to those with both normal levels of vitamin A and E(OR=11.61,95%CI:8.65-15.58).Conclusion Serum vitamin A and vitamin E concentrations during pregnancy were associated with preeclampsia.Vitamin E deficiency in first trimester is a risk factor for preeclampsia.Monitoring vitamin A and E concentrations in early pregnancy can help identify high-risk individuals for preeclampsia.

关 键 词：孕期 维生素A 维生素E 子痫前期 

分 类 号：R17[医药卫生—妇幼卫生保健] R71[医药卫生—公共卫生与预防医学]