双胎妊娠对女性远期高血压患病风险影响分析  

Impact of twin pregnancy on the long-term risk of hypertension in women

作　　者：宋静思 钟军辉 李楠[1] 张亚黎[1] 李智文[1] SONG Jingsi;ZHONG Junhui;Li Nan;ZHANG Yali;LI Zhiwen(Institute of Reproductive and Child Health,Peking University,National Health Commission Key Laboratory of Reproductive Health,Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China)

机构地区：[1]北京大学生育健康研究所/国家卫生健康委员会生育健康重点实验室(北京大学公共卫生学院),北京大学公共卫生学院流行病与卫生统计学系,100191

出　　处：《中国生育健康杂志》2025年第2期121-126,共6页Chinese Journal of Reproductive Health

摘　　要：目的探讨双胎妊娠对女性远期高血压患病风险的影响。方法本研究的数据来自于一个正在进行的孪生子调查研究。整个孪生子调查研究计划招募妊娠时间在1990年-2010年期间的1000名双胎妊娠的女性及其子女,同时配对同乡镇同时期妊娠的(时间相差不到一年)约1000名单胎妊娠女性及其子女,参加问卷调查。本研究使用了自2021年6月至2023年9月共收集到来自河北省四个县/区(满城、香河、乐亭和丰润)的1686份母亲问卷数据,排除缺乏高血压确诊信息者,确诊高血压时间在妊娠前、妊娠期间及在分娩后两年内者及出生日期、身高、体重、生活习惯及饮食习惯等关键信息缺失者,最终有1550份问卷纳入分析,其中双胎妊娠的女性(双胎组)769例,单胎妊娠的女性(单胎组)781例。描述参与调查女性的基本特征信息,应用Kaplan-Meier曲线分析累计高血压患病率和Cox回归探索双胎妊娠对女性远期高血压患病风险的影响。结果双胎组高血压患病率为8.8%(68/769),显著高于单胎组高血压患病率[5.8%(45/781),P<0.05]。Cox单因素分析发现,双胎是高血压的危险因素(HR=1.57,95%CI:1.07~2.28)。调整了年龄、体质指数、受教育程度、饮茶频率、吸烟及饮酒情况等因素后,双胎妊娠依然是高血压的独立危险因素(调整后HR=1.55,95%CI:1.06~2.27)。结论双胎妊娠为女性高血压的独立危险因素,应加强对双胎妊娠女性的长远期高血压风险管理。Objective To investigate the effect of twin pregnancy on the long term risk of hypertension in women.Methods Data were derived from an ongoing twin survey study which aims to recruit 1000 women and their children who had twin pregnancies during 1990~2010,along with a matched control group of approximately 1000 women with singleton pregnancy and their children.Women were matched based on the same township and with pregnancy dates within less than a year.Questionnaires data were collected from 1686 mother from four counties/districts in Hebei Province(Mancheng,Xianghe,Leting,and Fengrun)from Jun 2021 to September 2023.Exclusion criteria included lack of confirmed hypertension diagnosis,diagnosis of hypertension before pregnancy,during pregnancy,or within two years postpartum,and missing critical information such as date of birth,height,weight,lifestyle,and dietary habits.Finally,a total of 1550 women were included in the analysis.There were 769 women with twin pregnancies(twin group)and 781 women with singleton pregnancies(singleton group).Basic characteristics of these women were described.Kaplan-Meier curve was used to analyze the cumulative prevalence of hypertension,and Cox regression was used to explore the influence of twin pregnancy on hypertension in women.Results The incidence of hypertension in the twin group was 8.8%(68/769),which was significantly higher than the singleton group(5.8%,45/781).Univariate Cox analysis revealed that twin pregnancy was a risk factor for hypertension(HR=1.57,95%CI:1.07-2.28).After adjusting for age,body mass index,education level,frequency of tea consumption,smoking,and alcohol consumption,twin pregnancy remained an independent risk factor for hypertension(adjusted HR=1.55,95%CI:1.06-2.27).Conclusion Twin pregnancy is an independent risk factor for hypertension in women.Risk management of long-term hypertension in women with twin pregnancy should be strengthened.

关 键 词：双胎妊娠 女性 高血压 影响因素 

分 类 号：R17[医药卫生—妇幼卫生保健]