Photoredox-catalyzed synthesis of α,α-difluoromethyl-β-alkoxysulfones from sulfur dioxide  

作　　者：Minjun Yin Yuhui Lin Manli Zhuang Wei Xiao Jie Wu 

机构地区：[1]School of Pharmaceutical and Chemical Engineering&Institute for Advanced Studies,Taizhou University,Taizhou 318000,China [2]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China [3]School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007,China [4]Key Laboratory of the Ministry of Education for Advanced Catalysis Materials,Zhejiang Normal University,Jinhua 321004,China

出　　处：《Chinese Chemical Letters》2025年第3期248-252,共5页中国化学快报(英文版)

基　　金：Financial support from National Natural Science Foundation of China(Nos.22201202,22171206 and 22371201);Natural Science Foundation of Zhejiang Province(No.LZ23B020001);Open Foundation of Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers(No.E22307);Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(No.2020ZD04);Open Research Fund of Key Laboratory of the Ministry of Education for Advanced Catalysis Materials and Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces,Zhejiang Normal University。

摘　　要：A photoredox-catalyzed synthesis ofα,α-difluoromethyl sulfones from sulfur dioxide with readily available gem–difluoroalkenes is reported.This protocol features mild reaction conditions,broad substrate scope and good functional group compatibility,giving rise to the targetα,α-difluoromethyl sulfones in moderate to excellent yields.Mechanistic studies indicate that this reaction is initiated by an aryl radical with the insertion of sulfur dioxide.

关 键 词：Sulfur dioxide gem-Difuloroalkenes Photoredox catalysis α α-Difluoromethyl-β-alkoxysulfones Arylsulfonyl radical 

分 类 号：O621.3[理学—有机化学]