One-step preparation of biocompatible amphiphilic dimer nanoparticles with tunable particle morphology and surface property for interface stabilization and drug delivery  

作　　者：Xingqun Pu Rongrong Liu Yuting Xie Chenjing Yang Jingyi Chen Baoling Guo Chun-Xia Zhao Peng Zhao Jian Ruan Fangfu Ye David A Weitz Dong Chen 

机构地区：[1]Department of Medical Oncology,The First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China [2]Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325001,China [3]College of Energy Engineering and State Key Laboratory of Clean Energy Utilization,Zhejiang University,Hangzhou 310003,China [4]John A.Paulson School of Engineering and Applied Sciences,Harvard University,Cambridge,MA 02138,United States [5]School of Chemical Engineering and Advanced Materials,The University of Adelaide,Adelaide,SA 5005,Australia [6]Zhejiang Key Laboratory of Smart Biomaterials,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310027,China

出　　处：《Chinese Chemical Letters》2025年第3期345-350,共6页中国化学快报(英文版)

基　　金：supported by National Natural Science Foundation of China(No.22278352);National Key Research and Development Program of China(No.2021YFC3001100);Longyan City Science and Technology Plan Project(No.2020LYF17043);Longyan City Science and Technology Plan Project(No.2020LYF17042);ARC Discovery Project(No.DP200101238)and NHMRC Investigator Grant(No.APP2008698);supported by the Harvard Materials Research Science and Engineering Center(No.DMR2011754)。

摘　　要：Biocompatible amphiphilic nanoparticles(NPs)with tunable particle morphology and surface property are important for their applications as functional materials.However,previously developed methods to prepare amphiphilic NPs generally involve several steps,especially an additional step for surface modification,greatly hindering their largescale production and widespread applications.Here,a versatile one-step strategy is developed to prepare biocompatible amphiphilic dimer NPs with tunable particle morphology and surface property.The amphiphilic dimer NPs,which consist of a hydrophobic shellac bulb and a hydrophilic poly(lactic acid)(PLA)bulb with PLA-poly(ethylene glycol)(PEG)on the bulb surface,are prepared in a single step by controlled co-precipitation and self-assembly.Amphiphilic PLA-PEG/shellac dimer NPs demonstrate excellent tunability in particle morphology,thus showing good performances in controlling the interfacial curvature and emulsion type.In addition,temperatureresponsive PLA-poly(N-isopropyl acrylamide)(PNIPAM)/shellac dimer NPs are prepared following the same method and emulsions stabilized by them show temperature-triggered response.The applications of PLA-PEG-folic acid(FA)/shellac dimer NPs for drug delivery have also been demonstrated,which show a very good performance.The strategy of preparing the dimer NPs is green,scalable,facile and versatile,which provides a good platform for the design of dimer NPs with tunable particle morphology and surface property for diverse applications.

关 键 词：Janus particle Amphiphilic particle Dimer particle Colloidal surfactant Pickering emulsion Drug delivery 

分 类 号：O63[理学—高分子化学]