Chaeglobol A,an unusual octocyclic sterol with antifungal activity from the marine-derived fungus Chaetomium globosum HBU-45  

作　　者：Yun-Feng Liu Hui-Fang Du Ya-Hui Zhang Zhi-Qin Liu Xiao-Qian Qi Du-Qiang Luo Fei Cao 

机构地区：[1]College of Pharmaceutical Sciences,Key Laboratory of Pharmaceutical Quality Control of Hebei Province,Hebei University,Baoding 071002,China [2]College of Horticulture,Hebei Agricultural University,Baoding 071001,China [3]College of Life Sciences,Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China,State Key Laboratory of New Pharmaceutical Preparations and Excipients,Hebei University,Baoding 071002,China

出　　处：《Chinese Chemical Letters》2025年第3期407-410,共4页中国化学快报(英文版)

基　　金：funded by the S&T Program of Hebei(No.21323202D);the Natural Science Interdisciplinary Research Program of Hebei University(No.DXK201913);the Natural Sci-ence Foundation of Hebei Province of China(Nos.H2024201028,H2020201029);the Excellent Youth Research Innovation Team of Hebei University(No.QNTD202406);the Hebei University Research and Innovation Team(No.IT2023C1);the Innovation Capacity Improvement Plan of Hebei Province(No.20567605H);the National Training Program of Innovation and Entrepreneurship for Undergraduates(No.DC2024177)。

摘　　要：Chemical investigation of the marine-derived fungus Chaetomium globosum HBU-45 led to the discovery of chaeglobol A(1).Its structure was determined by spectroscopic analysis,computational electronic circular dichroism(ECD)/optical rotatory dispersion(ORD)methods,and X-ray crystallography.Compound 1 represents a new skeleton with an uncommon 6/6/6/5/6/5/6/5 octacyclic system,which is presumably biosynthesized via a[4+2]cycloaddition and an enzymatic cyclization.Chaeglobol A(1)exhibited inhibitory activity against B.dothidea by destroying cell membrane integrity and causing oxidative damage within the cells.

关 键 词：Marine-derived fungus Chaetomium globosum Octocyclic sterol Antifungal activity Single-crystal X-ray diffraction 

分 类 号：R284[医药卫生—中药学]