A new type of ArsR transcriptional repressor controls transcription of the arsenic resistance operon of Arsenicibacter rosenii SM-1  

作　　者：Yujie Zhang Wenjun Wu Ke Huang Fang-Jie Zhao 

机构地区：[1]Jiangsu Key Laboratory for Organic Waste Utilization,Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization,College of Resources and Environmental Sciences,Nanjing Agricultural University,Nanjing,China

出　　处：《mLife》2025年第1期96-100,共5页微生物(英文)

基　　金：supported by the Natural Science Foundation of China(Grant Nos.42077210 and 41930758 to Ke Huang and Fang-jie Zhao,respectively).

摘　　要：Impact statement Arsenic is the most common toxic metalloid in the environment.Nearly all organisms have genes for arsenic detoxification.Arsenic detoxification genes are frequently organized in chromosomal or plasmid-encoded arsenic resistance(ars)operons,which are commonly regulated by members of the ArsR transcriptional repressors.To date,three As(Ⅲ)-responsive ArsRs with different As(III)binding sites have been identified.Here,we identify a new type of As(Ⅲ)-responsive ArsR repressor that has an atypical As(Ⅲ)binding site and controls transcription of the ars operon of Arsenicibacter rosenii SM-1.Our results provide new insights into the classification and evolution relationship of the ArsR transcriptional repressors.

关 键 词：ars operon Ars responsive toxic metalloid evolution relationship ArsR transcriptional repressor arsenic resistance arsr repressor 

分 类 号：Q78[生物学—分子生物学]