围绝经期女性饮食模式和膳食炎症指数与骨密度的相关性  

Correlation between dietary pattern,dietary inflammatory index and bone mineral density in perimenopausal women

作　　者：张爱慕 吴蓓蕾 ZHANG Ai-mu;WU Bei-lei(Department of Obstetrics and Gynecology,Wenzhou Central Hospital,Wenzhou,Zhejiang 325000,China)

机构地区：[1]温州市中心医院妇产科,浙江温州325000

出　　处：《中国妇幼保健》2025年第6期1128-1132,共5页Maternal and Child Health Care of China

基　　金：浙江省温州市基础性医疗卫生科技项目(Y20210357)。

摘　　要：目的探讨围绝经期女性饮食模式、膳食炎症指数(DII)与骨密度的相关性。方法前瞻性选取2020年12月—2022年9月温州市中心医院接受体检的213例围绝经期女性为研究对象,分析研究对象的一般资料,根据骨密度的高低将所有研究对象分为骨量正常组、骨量减少组以及骨质疏松组,采用食物频率调查表(FFQ)分析3组患者的饮食模式以及DII同骨密度间的相关性;根据DII将所有研究对象分为抗炎组(DII>0)和促炎组(DII<0),分析DII同炎症因子水平的相关性。结果骨量正常组钙补充剂、蛋类、奶类、畜禽肉类食品、水果类、绿叶蔬菜类、大豆类及其制品每日摄入量显著多于骨质疏松组和骨量减少组,而骨量减少组患者显著多于骨质疏松组(P<0.05);骨质疏松组和骨量减少组膳食炎症指数分别为(1.64±0.68)、(0.52±0.28),均高于骨量正常组(-1.25±0.97),差异有统计学意义(F=303.285,P<0.001),骨质疏松组膳食炎症指数为(1.64±0.68),高于骨量减少组(0.52±0.28),差异有统计学意义(t=13.314,P<0.001);促炎组CRP水平(3.69±1.54)mg/L高于抗炎组(2.81±0.64)mg/L,差异无统计学意义(t=-0.450,P>0.05),促炎组IL-1β(1.57±1.35)pg/ml、IL-6(2.91±0.70)pg/ml、IL-4(1.85±0.75)pg/ml、IL-10(2.23±1.08)ng/mL、TNF-α(2.01±0.21)ng/L和抗炎组IL-1β(1.66±0.52)pg/ml、IL-6(2.12±0.34)pg/ml、IL-4(1.66±0.52)pg/ml、IL-10(2.28±0.72)ng/mL、TNF-α(1.86±1.12)ng/L组间比较差异均无统计学意义(均P>0.05)。结论围绝经期女性饮食模式、膳食炎症指数与骨密度三者之间均存在紧密联系。Objective To explore the correlation between dietary pattern,dietary inflammatory index(DII)and bone mineral density in perimenopausal women.Methods A total of 213 perimenopausal women who received physical examination Wenzhou Central Hospital from December 2020 to September 2022 were prospectively selected as the research objects,and the general data of the research objects were analyzed.According to the bone density,all the research objects were divided into normal group,osteopenia group and osteoporosis group,and the food frequency questionnaire(FFQ)was used to analyze the dietary patterns of the three groups and the correlation between DII and bone density.According to DII,all the subjects were divided into anti-inflammatory group(DII>0)and pro-inflammatory group(DII<0),and the correlation between DII and inflammatory factors was analyzed.Results The daily intake of calcium supplements,eggs and dairy products,livestock and poultry meat products,fruits,green leafy vegetables,soybeans and their products in the normal bone mass group was significantly higher than that in the osteoporosis group and the bone mass reduction group,while the number of patients in the bone mass reduction group was significantly higher than that in the osteoporosis group(P<0.05);The dietary inflammation index(1.64±0.68)and(0.52±0.28)of the osteoporosis group and the bone loss group were both higher than those of the normal bone loss group(-1.25±0.97),the difference is statistically significant(F=303.285,P<0.001).The dietary inflammation index(1.64±0.68)of the osteoporosis group was higher than that of the bone loss group(0.52±0.28),and the inter group comparison difference was statistically significant(t=13.314,P<0.001).The CRP levels in the pro-inflammatory group(3.69±1.54)mg/L were higher than those in the anti-inflammatory group(2.81±0.64)mg/L,there was no statistically significant difference(t=-0.450,P>0.05).The pro-inflammatory group had IL-1β(1.57±1.35)pg/ml,IL-6(2.91±0.70)pg/ml,IL-4(1.85±0.75)pg/ml,IL-10(2.23±1.08)ng

关 键 词：围绝经期 饮食模式 膳食炎症指数 骨密度 相关性 

分 类 号：R711[医药卫生—妇产科学]