基于褪黑素内外源性调节对蒙药治疗失眠症状的析论  

Analysis of Mongolian Medicine in Treating Insomnia Symptoms Based on Endogenous and Exogenous Regulation of Melatonin

作　　者：胡苏叶 黄格尔柱拉 俊俊 敖敦格日乐[1,2] 拉喜那木吉拉 HU Suye;HUANG Geerzhula;JUN Jun;AO Dungerile;LA Xinamujila(College of Mongolian Medicine,Inner Mongolia University for Nationalities,Tongliao 028000,China;Key Laboratory of Quality Control of Traditional Chinese Medicine〔Mongolian Medicine〕,State Food and Drug Administration,Tongliao 028000,China)

机构地区：[1]内蒙古民族大学蒙医药学院,通辽028000 [2]国家药监局中药〔蒙药〕质量控制重点实验室,通辽028000

出　　处：《世界睡眠医学杂志》2025年第1期215-218,共4页World Journal of Sleep Medicine

基　　金：内蒙古自治区教育厅中(蒙)药资源开发利用集成攻关大平台项目(KYPT23004)。

摘　　要：失眠是神经系统疾病中最常见的睡眠障碍之一。遗传、环境、行为和生理等因素都涉及失眠的病因和病理生理。治疗失眠的有效方法包括行为、认知和药物干预。在药理学干预措施中,人们一直关注它们相对于适度疗效的安全性。然而,褪黑素(MLT)作为最初在动物中发现的消炎类小分子,在调节生物钟和促进睡眠方面发挥着对人类有益的作用,如清除自由基、抗氧化、抗衰老、抗肿瘤、调节昼夜、改善睡眠等。近几年来,传统蒙药治疗失眠有显著效果,这些蒙药单味药及复方药都含有较多的褪黑素,可内外源性补充体内褪黑素分泌。本文基于褪黑素内外源性调节来探讨传统蒙药改善失眠的研究,为蒙医临床用药铺垫基础和依据。Insomnia is one of the most common sleep disorders in neurological diseases.Factors such as genetics,environment,behavior,and physiology are all involved in the etiology and pathophysiology of insomnia.Effective approaches to treating insomnia include behavioral,cognitive,and pharmacological interventions.Their safety relative to modest efficacy has been concerned in pharmacological interventions.However,melatonin(MLT),as a small anti-inflammatory molecule originally discovered in animals,plays a beneficial role in regulating the circadian clock and promoting sleep,such as scavenging free radicals,antioxidant,anti-aging,anti-tumor,regulating day and night,improving sleep,etc.In recent years,traditional Mongolian medicine has achieved remarkable effects in treating insomnia.These Mongolian medicines both single and compound medicines contain more melatonin,which can supplement melatonin secretion in the body internally and externally.Based on the endogenous and exogenous regulation of melatonin,this paper discusses the research of traditional Mongolian medicine to improve insomnia,and lays the foundation and basis for clinical medication of Mongolian medicine.

关 键 词：失眠 褪黑素 蒙药 内源性 外源性 

分 类 号：R338.63[医药卫生—人体生理学]