近十年柴胡桂枝干姜汤加减治疗失眠的系统评价  

A Systematic Review of Modified Chaihu Guizhi Ganjiang Decoction in the Treatment of Insomnia Over the Past Decade

作　　者：刘海儿 林璆 蔡婉禧 林燕萍[1] 苏文理[2] LIU Haier;LIN Qiu;CAI Wanxi;LIN Yanping;SU Wenli(Fujian University of Traditional Chinese Medicine,Fuzhou 350000,China;Sanming Integrated Medicine Hospital,Sanming 365001,China)

机构地区：[1]福建中医药大学,福州350000 [2]三明市中西医结合医院,三明365001

出　　处：《世界睡眠医学杂志》2025年第1期224-229,共6页World Journal of Sleep Medicine

基　　金：三明市卫生健康科技创新项目(2023-S-72)。

摘　　要：目的:系统评价柴胡桂枝干姜汤加减治疗失眠的有效性。方法:通过检索中国期刊全文数据库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(CSPD)、PubMed和Web of Science,收集柴胡桂枝干姜汤加减治疗失眠的随机对照试验(RCT)。数据分析采用RevMan 5.4软件,对纳入的研究进行Meta分析,评价其临床疗效总有效率、匹兹堡睡眠质量指数(PSQI)评分。结果:一共检索到148篇文献,共纳入10项研究,总计681例患者。Meta分析结果显示,柴胡桂枝干姜汤加减治疗失眠的临床总有效率显著高于对照组,差异有统计学意义(RR=1.36,95%CI为1.25~1.49,P<0.00001),且PSQI评分改善更显著,差异有统计学意义(MD=-2.28,95%CI为-3.70~-0.86,P=0.002)。结论:现有的研究证据表明,柴胡桂枝干姜汤加减治疗失眠可有效提高临床疗效,改善睡眠质量,且不良反应较少,具有良好的安全性。但目前尚未能证明其联合其他疗法在降低PSQI评分方面有明显优势。Objective:To systematically evaluate the effectiveness of modified Chaihu Guizhi Ganjiang Decoction in the treatment of insomnia.Methods:Randomized controlled trials(RCT)involving ChaiHu GuiZhi GanJiang Decoction in the treatment of chronic urticaria were searched and identified from China Journal Full-Text Database(CNKI),VIP Database for Chinese Technical Periodicals(VIP),Wanfang Data Knowledge Service Platform,PubMed and Web of Science.Meta-analysis was performed on the included RCTs to evaluate the overall clinical effectiveness and Pittsburgh Sleep Quality Index(PSQI)score.Results:A total of 148 literatures were retrieved,and 10 literatures were included,involving 681 insomnia patients.The results of Meta-analysis showed that the total clinical effective rate of modified Chaihu Guizhi Ganjiang Decoction group in treating insomnia is significantly higher than that in the control group,RR=1.36,95%CI 1.25 to 1.49,P<0.00001.Additionally,the Pittsburgh Sleep Quality Index(PSQI)score is more significant in the control group(MD=-2.28,95%CI-3.70 to-0.86,P=0.002).Conclusion:Current evidence showed that modified Chaihu Guizhi Ganjiang Decoction in the treatment of insomnia can effectively improve clinical efficacy and sleep quality in treating insomnia,with fewer adverse reactions and good safety.However,there is insufficient evidence to demonstrate its combined use with other therapies has a significant advantage in reducing PSQI scores.

关 键 词：柴胡桂枝干姜汤 中药 失眠 睡眠障碍 疗效 PSQI META分析 系统评价 

分 类 号：R856.2[医药卫生—航空、航天与航海医学] R338.63[医药卫生—临床医学]