线粒体自噬改善心肌梗死后心肌纤维化及其中医药干预的研究进展  

Research Progress of Mitochondrial Autophagy in Improving Myocardial Fibrosis after Myocardial Infarction and Intervention of Traditional Chinese Medicine

作　　者：朱子一 何贵新[2] 秦伟彬 宋惠 张利文 唐伟智 杨斐斐 刘凌云 欧阳彬 ZHU Ziyi;HE Guixin;QIN Weibin;SONG Hui;ZHANG Liwen;TANG Weizhi;YANG Feifei;LIU Lingyun;OUYANG Bin(Guangxi University of Chinese Medicine,Nanning 530200,China;The Second Cardiovascular District,the First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530022,China)

机构地区：[1]广西中医药大学,广西壮族自治区南宁市530200 [2]广西中医药大学附属第一医院心血管二区,广西壮族自治区南宁市530022

出　　处：《中国全科医学》2025年第18期2294-2300,共7页Chinese General Practice

基　　金：广西自然科学基金资助项目(2020GXNSFDA297020);广西中医药大学桂派中医药传承创新团队-疑难重症中医诊疗研究团队(2022A001);广西中医药大学自然科学基金面上项目(2023MS023)。

摘　　要：线粒体作为细胞“守护者”,在生物体中具有复杂的生理功能。线粒体自噬作为一种选择性的自噬方式,在清除损伤的线粒体、维持线粒体的数量及功能等方面起着关键的作用。心肌细胞在心肌梗死后会经历缺血和再灌注损伤,并伴随着线粒体功能的异常及数目的增多,导致心肌纤维化的形成。线粒体自噬的激活对于改善心肌损伤和心肌纤维化具有潜在的治疗价值。本文对线粒体自噬在改善心肌梗死后心肌纤维化具体通路的作用机制进行总结,以及中医药干预线粒体自噬的相关研究进展进行综合阐述,以期为心肌梗死后心肌纤维化的临床治疗提供更为有效的策略。Mitochondria,as the guardians of cells,have complex physiological functions in living organisms.Mitochondrial autophagy,as a selective autophagy method,plays a crucial role in clearing damaged mitochondria,maintaining the quantity and function of mitochondria,and so on.After myocardial infarction,myocardial cells undergo ischemia and reperfusion injury,accompanied by abnormal mitochondrial function and an increase in the number,leading to the formation of myocardial fibrosis.The activation of mitochondrial autophagy has potential therapeutic value for im-proving myocardial injury and fibrosis.This article will summarize the specific pathways through which mitochondrial autophagy improves myocardial fibrosis after myocardial infarction,and comprehensively elaborate on the research progress of traditional Chinese medicine intervention in mitochondrial autophagy,in order to provide more effective strategies for the clinical treatment of myocardial fibrosis after myocardial infarction.

关 键 词：心肌梗死 线粒体自噬 心肌纤维化 中医药 综述 

分 类 号：R542.22[医药卫生—心血管疾病]