钙敏感受体在心肌损伤中介导的信号通路研究进展  

Calcium Sensitive Receptors Mediate Signaling Pathways in Myocardial Injury

作　　者：沈明妹 吕俞娇 张尚博 周鑫辰 董姝含 张卓 刘永超 SHEN Mingmei;LYU Yujiao;ZHANG Shangbo;ZHOU Xinchen;DONG Shuhan;ZHANG Zhuo;LIU Yongchao(College of Medical Technology,Beihua University,Jilin 132013,China)

机构地区：[1]北华大学医学技术学院,吉林省吉林市132013

出　　处：《中国全科医学》2025年第18期2301-2306,共6页Chinese General Practice

基　　金：吉林省科学技术厅吉林省科技发展计划项目(20220402072GH);北华大学研究生创新计划项目([2023]020)。

摘　　要：钙敏感受体(CaSR)是一种G蛋白偶联受体,可以诱导高度扩散的信使以激活各种细胞反应。最近研究认为CaSR介导内质网、线粒体、细胞核之间的信号通信,且此过程与心肌损伤相关。心肌细胞为永久细胞,不可再生。因此,本文将重点介绍CaSR在心肌损伤中的相关调控机制,梳理其介导的复杂细胞内信号转导网络,为寻找心肌损伤治疗新靶点提供思路。Calcium sensing receptor(CaSR)is a G-protein-coupled receptor that induces highly diffused messengers to activate various cellular responses.Recently,it has been suggested that CaSR mediates signal communication among endoplasmic reticulum,mitochondria,and nucleus,and this process is associated with myocardial injury.Cardiomyocytes are permanent cells and do not regenerate.Therefore,this paper will focus on the relevant regulatory mechanisms of CaSR in myocardial injury,comb out the complex intracellular signal transduction network mediated by CASR,and provide ideas for finding new therapeutic targets for myocardial injury.

关 键 词：心肌损伤 心肌肥大 心肌纤维化 钙敏感受体 

分 类 号：R541[医药卫生—心血管疾病]