尘肺病动物模型的研究进展  

Research progress on animal models of pneumoconiosis

作　　者：何莹莹 王丽娜[2] 孙德兴 贾志财 李倩 HE Yingying;WANG Lina;SUN Dexing;JIA Zhicai;LI Qian(School of Public Health,Gansu University of Chinese Medicine,Lanzhou,Gansu 730000,China;不详)

机构地区：[1]甘肃中医药大学公共卫生学院,甘肃兰州730000 [2]甘肃中医药大学第三附属医院 [3]甘肃中医药大学中医临床学院

出　　处：《中国工业医学杂志》2025年第1期58-60,共3页Chinese Journal of Industrial Medicine

基　　金：甘肃省自然科学基金(编号:23JRRD0004);甘肃省科技计划资助项目(编号:23JDKD0001)。

摘　　要：尘肺是由生产环境中存在石英粉尘所导致的肺纤维化,其发病机制比较复杂。建立完善的尘肺病动物模型可以为发病机制及预防研究提供理论依据。通过对文献的梳理概括,总结目前以气管切开暴露和非气管切开暴露方式建立尘肺病动物模型的常用方法,分析各种动物模型优、缺点,为尘肺病基础研究与治疗策略有效性评价提供参考。Pneumoconiosis is a pulmonary fibrosis caused by the presence of quartz dust in the production environment,and its pathogenesis is relatively complex.Establishing a comprehensive animal model of pneumoconiosis can provide theoretical basis for the pathogenesis and prevention.By reviewing and summarizing the literature,the commonly used methods for establishing animal models of pneumoconiosis are summarized.Based on the analysis of the advantages and disadvantages of various animal models,reference is provided for the basic research and effectiveness evaluation of pneumoconiosis.

关 键 词：尘肺病 动物模型 进展 

分 类 号：R135.2[医药卫生—劳动卫生] R994.3[医药卫生—公共卫生与预防医学]